Artículos de revista

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    Melatonin: a neurotrophic factor?
    (MDPI, 2022) Miranda-Riestra, Armida; Estrada-Reyes, Rosa; Torres-Sanchez, Erandis D.; Carreño-García, Silvia; Gabriel Ortiz, Genaro; Benítez-King, Gloria; Laboratorio de Neurofarmacología, Subdirección de Investigaciones Clínicas, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calzada México-Xochimilco 101, San Lorenzo Huipulco, Tlalpan 14370, Mexico City, Mexico; genarogabriel@yahoo.com (G.G.O.) ; bekin@imp.edu.mx (G.B.-K.)
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    Further evidence of the melatonin calmodulin interaction: effect on CaMKII activity
    (MDPI, 2022) Argueta, Jesús; Solís-Chagoyán, Héctor; Estrada-Reyes, Rosa; Constantino-Jonapa, Luis A.; Oikawa-Sala, Julián; Velázquez-Moctezuma, Javier; Benítez-King, Gloria; Laboratorio de Neurofarmacología, Subdirección de Investigaciones Clínicas, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calzada México-Xochimilco 101, San Lorenzo Huipulco, Tlalpan, Mexico City 14370, Mexico; bekin@imp.edu.mx, bekin54@hotmail.com ( Gloria Benítez-King)
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    Low doses of ketamine and melatonin in combination produce additive antidepressant-like effects in mice
    (MDPI, 2021) Estrada-Reyes, Rosa; Quero-Chávez, Daniel B.; Trueta, Citlali; Miranda, Armida; Valdés-Tovar, Marcela; Alarcón-Elizalde, Salvador; Oikawa-Sala, Julián; Argueta, Jesús; Constantino-Jonapa, Luis A.; Muñoz-Estrada, Jesús; Dubocovich, Margarita L.; Benítez-King, Gloria; Laboratorio de Fitofarmacología, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calzada México-Xochimilco 101, San Lorenzo Huipulco, Tlalpan, Ciudad de México 14370, Mexico.; bekin@imp.edu.mx; bekin54@hotmail.com (Benítez-King, Gloria)
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    Melatonin rescues the dendrite collapse induced by the pro-oxidant toxin okadaic acid in organotypic cultures of rat hilar hippocampus
    (2020) Solís-Chagoyán, Héctor; Domínguez-Alonso, Aline; Valdés-Tovar, Marcela; Argueta, Jesús; Sánchez-Florentino, Zulay A.; Calixto, Eduardo; Benítez-King, Gloria; Laboratorio de Neurofarmacología, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Mexico City 14370, Mexico.; bekin@imp.edu.mx
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    MT2-like melatonin receptor modulates amplitude receptor potential in visual cells of crayfish during a 24-hour cycle
    (Elsevier Science INC, 360 Park Ave South, New York, NY 10010-1710 USA, 2009) Mendoza-Vargas, Leonor; Solís-Chagoyán, Héctor; Benítez-King, Gloria; Fuentes-Pardo, Beatriz; Univ Nacl Autonoma Mexico, Dept Fisiol, Fac Med, Mexico City 04510, DF, Mexico; bfpardo@servidor.unam.mx
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    Melatonin modulates cytoskeletal organization in the rat brain hippocampus
    (Elsevier Ireland LTD, Elsevier House, Brookvale Plaza, East Park Shannon, CO, Clare, 00000, Ireland, 2012) Jiménez-Rubio, Graciela; Ortíz-López, Leonardo; Benítez-King, Gloria; Inst Nacl Psiquiatria Ramon Fuente Muniz, SIC, Depto Neurofarmacol, Calzada Mexico Xochimilco 101, Mexico City 14370, DF, Mexico.; bekin@imp.edu.mx
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    Melatonin supplementation delays the decline of adult hippocampal neurogenesis during normal aging of mice
    (ELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS, 2012) Ramírez-Rodríguez, Gerardo; Vega-Rivera, Nelly M.; Benítez-King, Gloria; Castro-García, Mario; Ortíz-López, Leonardo; Laboratory of Neurogenesis, Division of Clinical Research, National Institute of Psychiatry, México, D.F., Mexico; gbernabe@imp.edu.mx
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    Melatonin Modulates Cell Survival of New Neurons in the Hippocampus of Adult Mice
    (Elsevier Science INC, 360 Park Ave South, New York, NY 10010-1710 USA, 2009) Ramírez-Rodríguez, Gerardo; Klempin, Friederike; Babu, Harish; Benítez-King, Gloria; Kempermann, Gerd; Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch, Berlin, Germany; gerd.kempermann@crt-dresden.de
    Regulation of adult hippocampal neurogenesis is influenced by circadian rhythm, affected by the manipulation of sleep, and is disturbed in animal models of affective disorders. These observations and the link between dysregulation of the circadian production of melatonin and neuropsychiatric disorders prompted us to investigate the potential role of melatonin in controlling adult hippocampal neurogenesis. In vitro, melatonin increased the number of new neurons derived from adult hippocampal neural precursor cells in vitro by promoting cell survival. This effect was partially dependent on the activation of melatonin receptors as it could be blocked by the application of receptor antagonist luzindole. There was no effect of melatonin on cell proliferation. Similarly, in the dentate gyrus of adult C57BL/6 mice in vivo, exogenous melatonin (8_mg/kg) also increased the survival of neuronal progenitor cells and post-mitotic immature neurons. Melatonin did not affect precursor cell proliferation in vivo and also did not influence neuronal and glial cell maturation. Moreover, melatonin showed antidepressant-like effects in the Porsolt forced swim test. These results indicate that melatonin through its receptor can modulate the survival of newborn neurons in the adult hippocampus, making it the first known exogenously applicable substance with such specificity
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    ROCK-regulated cytoskeletal dynamics participate in the inhibitory effect of melatonin on cancer cell migration
    (2009) Ortíz-López, Leonardo; Morales-Mulia, Sandra; Ramírez-Rodríguez, Gerardo; Benítez-King, Gloria
    Cell movement is generated by a driving force provided by dynamic cytoskeletal organization. Two main cytoskeletal-dependent features, essential for migration, are the highly cell polarized structure and focal adhesion complexes. Cell migration and substrate anchorage are finely regulated by external signaling exerted by growth factors and hormones. In particular, the serine threonine kinase activated by the small GTPase Rho, the Rho-associated protein kinase (ROCK), participate in both processes through regulation of actin rearrangements in lamellipodia, filopodia, ruffles, and stress fibers. Melatonin, the main product secreted by the pineal gland has oncostatic properties. In MCF-7 cells, 1 nm melatonin reduces migration and invasiveness through increased expression of two cell surface adhesion proteins, E-cadherin and _1-integrin. In this work, we studied the microfilament and microtubule rearrangements elicited by melatonin in migrating leader MCF-7 cells by a wound-healing assay. Additionally, cell anchorage was estimated by quantification of focal adhesions in MCF-7 cells cultured with melatonin. ROCK participation in the indole effects on anchorage and migration was explored by inhibition of the kinase activity with the specific inhibitor of ROCK, the Y-27632 compound. The results indicate that ROCK participates in the melatonin inhibitory effects on cell migration by changing cytoskeletal organization of leader MCF-7 cells. Also, they indicated that indole increased the number of focal contacts through ROCK. These results support the notion that melatonin inhibits cancer cell invasion and metastasis formation via ROCK-regulated microfilament and microtubule organization that converge in a migration/anchorage switch.
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    Haloperidol causes cytoskeletal collapse in N1E-115 cells through tau hyperphosphorylation induced by oxidative stress: Implications for neurodevelopment
    (ELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS, 2010) Benítez-King, Gloria; Ortíz-López, Leonardo; Jiménez-Rubio, Graciela; Ramírez-Rodríguez, Gerardo; Departamento de Neurofarmacología, Subdirección de Investigaciones Clínicas, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, México, D.F., México; bekin@imp.edu.mx