Relative risk of injury from acute alcohol consumption: modeling the dose-response relationship in emergency department data from 18 countries

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dc.contributor.affiliationStatistical and Data Services Department, Alcohol Research Group, Emeryville, CA, USA
dc.contributor.emailccherpitel@arg.org (Cheryl J. Cherpite)
dc.creatorCherpitel, Cheryl J.es_ES
dc.creatorYe, Yues_ES
dc.creatorBond, Jasones_ES
dc.creatorBorges, Guilhermees_ES
dc.creatorMonteiro, Maristelaes_ES
dc.date2015
dc.date.accessioned2025-08-08T17:37:43Z
dc.date.accessioned2026-03-27T15:32:20Z
dc.date.available2025-08-08T17:37:43Z
dc.date.issued2015
dc.date.published2015
dc.descriptionAims: To update and extend analysis of the dose-response relationship of injury and drinking by demographic and injury subgroups and country-level drinking pattern, and examine the validity and efficiency of the fractional polynomial approach to modeling this relationship. Design: Pair-matched case-cross-over analysis of drinking prior to injury, using categorical step-function and fractional polynomial analysis. Setting: Thirty-seven emergency departments (EDs) across 18 countries. Participants: A total of 13 119 injured drinkers arriving at the ED within 6 hours of the event. Measurements: The dose-response relationship was analyzed by gender, age, cause of injury (traffic, violence, fall, other) and country detrimental drinking pattern (DDP). Findings: Estimated risks were similar between the two analytical methods, with injury risk doubling at one drink [odds ratio (OR) = 2.3-2.7] and peaking at about 30 drinks. Although risk was similar for males and females up to three drinks (OR = 4.6), it appeared to increase more rapidly for females and was significantly higher starting from 20 drinks [female OR = 28.6; confidence interval (CI) = 16.8, 48.9; male OR = 12.8; CI = 10.1, 16.3]. No significant differences were found across age groups. Risk was significantly higher for violence-related injury than for other causes across the volume range. Risk was also higher at all volumes for DDP-3 compared with DDP-2 countries. Conclusions: There is an increasing risk relationship between alcohol and injury but risk is not uniform across gender, cause of injury or country drinking pattern. The fractional polynomial approach is a valid and efficient approach for modeling the alcohol injury risk relationship.es_ES
dc.formatPDFes_ES
dc.identifier2015es_ES
dc.identifier.doi10.1111/add.12755
dc.identifier.eissn1360-0443
dc.identifier.issn0965-2140
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.placeInglaterra
dc.identifier.urihttps://doi.org/10.1111/add.12755
dc.identifier.urihttps://pmc.ncbi.nlm.nih.gov/articles/PMC4302018/
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/8382
dc.language.isoenges_ES
dc.publisherWiley-Blackwelles_ES
dc.relation110(2):279-88
dc.relation.jnabreviadoADDICTION
dc.relation.journalAddiction
dc.rightsAcceso Cerradoes_ES
dc.subject.kwDetrimental drinking pattern
dc.subject.kwDose–response
dc.subject.kwEmergency department
dc.subject.kwGender
dc.subject.kwInjury cause
dc.subject.kwInjury risk
dc.titleRelative risk of injury from acute alcohol consumption: modeling the dose-response relationship in emergency department data from 18 countrieses_ES
dc.typeArtículoes_ES

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