Immunomodulatory effects mediated by serotonin

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dc.contributor.affiliationPsychiatric Genetics Department, Clinical Research Branch, National Institute of Psychiatry, "Ramón de la Fuente", Calzada México-Xochimilco 101, Colonia San Lorenzo Huipulco, Tlalpan, 14370 Mexico City, DF, Mexico
dc.contributor.emaillkuriaki@imp.edu.mx (Lenin Pavón)
dc.creatorArreola, Rodrigoes_ES
dc.creatorBecerril-Villanueva, Enriquees_ES
dc.creatorCruz-Fuentes, Carloses_ES
dc.creatorVelasco-Velázquez, Marco Antonioes_ES
dc.creatorGarcés-Alvarez, María Eugeniaes_ES
dc.creatorHurtado-Alvarado, Gabrielaes_ES
dc.creatorQuintero-Fabian, Sarayes_ES
dc.creatorPavón, Lenines_ES
dc.date2015
dc.date.accessioned2025-09-10T19:11:35Z
dc.date.accessioned2026-03-27T15:32:36Z
dc.date.available2025-09-10T19:11:35Z
dc.date.issued2015
dc.date.published2015
dc.descriptionSerotonin (5-HT) induces concentration-dependent metabolic effects in diverse cell types, including neurons, entherochromaffin cells, adipocytes, pancreatic beta-cells, fibroblasts, smooth muscle cells, epithelial cells, and leukocytes. Three classes of genes regulating 5-HT function are constitutively expressed or induced in these cells: (a) membrane proteins that regulate the response to 5-HT, such as SERT, 5HTR-GPCR, and the 5HT3-ion channels; (b) downstream signaling transduction proteins; and (c) enzymes controlling 5-HT metabolism, such as IDO and MAO, which can generate biologically active catabolites, including melatonin, kynurenines, and kynurenamines. This review covers the clinical and experimental mechanisms involved in 5-HT-induced immunomodulation. These mechanisms are cell-specific and depend on the expression of serotonergic components in immune cells. Consequently, 5-HT can modulate several immunological events, such as chemotaxis, leukocyte activation, proliferation, cytokine secretion, anergy, and apoptosis. The effects of 5-HT on immune cells may be relevant in the clinical outcome of pathologies with an inflammatory component. Major depression, fibromyalgia, Alzheimer disease, psoriasis, arthritis, allergies, and asthma are all associated with changes in the serotonergic system associated with leukocytes. Thus, pharmacological regulation of the serotonergic system may modulate immune function and provide therapeutic alternatives for these diseases.es_ES
dc.formatPDFes_ES
dc.identifier.doi10.1155/2015/354957
dc.identifier.eissn2314-7156
dc.identifier.issn2314-8861
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.placeEgipto
dc.identifier.urihttps://doi.org/10.1155/2015/354957
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/8409
dc.language.isoenges_ES
dc.publisherWileyes_ES
dc.relation2015:354957
dc.relation.jnabreviadoJ IMMUNOL RES
dc.relation.journalJournal of Immunology Research
dc.rightsAcceso Cerradoes_ES
dc.titleImmunomodulatory effects mediated by serotonines_ES
dc.typeArtículoes_ES

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