Proinflammatory cytokine levels in fibromyalgia patients are independent of body mass index

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dc.contributor.affiliationDepartment of Psychoimmunology, National Institute of Psychiatry "Ramon de la Fuente", Mexicoes_ES
dc.contributor.emaillkuriaki@imp.edu.mx.es_ES
dc.creatorHernández, María E.
dc.creatorBecerril, Enrique
dc.creatorPérez, Mayra
dc.creatorLeff, Philippe
dc.creatorAntón, Benito
dc.creatorEstrada, Sergio
dc.creatorEstrada, Iris
dc.creatorSarasa, Manuel
dc.creatorSerrano, Enrique
dc.creatorPavón, Lenin
dc.creator.identificador"HEGE630202MDFRTG02">Hernández Gutiérrez, María Eugeniaes_ES
dc.date.accessioned2017-06-30T01:37:29Z
dc.date.accessioned2026-03-27T14:47:03Z
dc.date.available2017-06-30T01:37:29Z
dc.date.issued2010es_ES
dc.date.published2010es_ES
dc.description.abstractotrodiomaBACKGROUND: Fibromyalgia (FM) is characterized by chronic, widespread muscular pain and tenderness and is generally associated with other somatic and psychological symptoms. Further, circulatory levels of proinflammatory cytokines (IL-1beta, TNF-alpha, and IL-6) may be altered in FM patients, possibly in association with their symptoms. Recently, rises in BMI have been suggested to contribute to increased circulating levels of proinflammatory cytokines in FM patients. Our aim was to measure the circulatory levels of proinflammatory cytokines to determine the influence of BMI on these levels in FM patients and healthy volunteers (HVs). In Spanish FM patients (n = 64) and HVs (n = 25), we measured BMI and serum concentrations of proinflammatory cytokines by capture ELISA. FINDINGS: There were significant differences in BMI levels between FM patients (26.40 +/- 4.46) and HVs (23.64 +/- 3.45) and significant increase in IL-6 in FM patients (16.28 +/- 8.13 vs 0.92 +/- 0.32 pg/ml) (P < 0.001). IL-1beta and TNF-alpha decreased in FM patients compared with HVs. By ANCOVA, there was no significant association between BMI and TNF-alpha (F = 0.098, p = 0.75) or IL-6 (F = 0.221, p = 0.63) levels in FM patients. CONCLUSIONS: Our analysis in FM patients of BMI as a covariate of proinflammatory cytokines levels showed that serum TNF-alpha and IL-6 levels are independent of BMI. Further studies are necessary to dissect these findings and their implication in future therapeutic approaches for FM patientses_ES
dc.description.monthJunes_ES
dc.identifier1490es_ES
dc.identifier.citationJuan Carlos Bautista Ramírezes_ES
dc.identifier.doi10.1186/1756-0500-3-156es_ES
dc.identifier.eissn1756-0500es_ES
dc.identifier.issn1756-0500es_ES
dc.identifier.numero156es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.paginacion1-5es_ES
dc.identifier.placeInglaterraes_ES
dc.identifier.urihttp://www.biomedcentral.com/1756-0500/3/156es_ES
dc.identifier.urihttps://doi.org/10.1186/1756-0500-3-156es_ES
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/6171
dc.identifier.volumen3es_ES
dc.language.isoenges_ES
dc.relation3 (156) 1-5 p.es_ES
dc.relationversión del editores_ES
dc.relation.jnabreviadoBMC RES NOTESes_ES
dc.relation.journalBiomed Central Research Noteses_ES
dc.rightsacceso cerradoes_ES
dc.titleProinflammatory cytokine levels in fibromyalgia patients are independent of body mass indexes_ES
dc.typearticlees_ES

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