Modified peptides and organic metabolites of cyanobacterial origin with antiplasmodial properties

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dc.contributor.affiliationPosgrado en Ciencias Genómicas, Universidad Autónoma de la Ciudad de México (UACM), San Lorenzo 290, Col. Del Valle, 03100, Mexico City, Mexico.
dc.contributor.emailmaria.alvarez@uacm.edu.mx
dc.creatorAlvarez-Sánchez, Maria Elizbeth
dc.creatorArreola, Rodrigo
dc.creatorQuintero-Fabián, Saray
dc.creatorPérez-Sánchez, Gilberto
dc.date2024
dc.date.accessioned2026-06-18T18:29:21Z
dc.date.issued2024
dc.date.published2024
dc.descriptionAs etiological agents of malaria disease, Plasmodium spp. parasites are responsible for one of the most severe global health problems occurring in tropical regions of the world. This work involved compiling marine cyanobacteria metabolites reported in the scientific literature that exhibit antiplasmodial activity. Out of the 111 compounds mined and 106 tested, two showed antiplasmodial activity at very low concentrations, with IC50 at 0.1 and 1.5 nM (peptides: dolastatin 10 and lyngbyabellin A, 1.9% of total tested). Examples of chemical derivatives generated from natural cyanobacterial compounds to enhance antiplasmodial activity and Plasmodium selectivity can be found in successful findings from nostocarboline, eudistomin, and carmaphycin derivatives, while bastimolide derivatives have not yet been found. Overall, 57% of the reviewed compounds are peptides with modified residues producing interesting active moieties, such as α- and β-epoxyketone in camaphycins. The remaining compounds belong to diverse chemical groups such as alkaloids, macrolides, polycyclic compounds, and halogenated compounds. The Dolastatin 10 and lyngbyabellin A, compounds with antiplasmodial high activity, are cytoskeletal disruptors with different protein targets.
dc.formatPDF
dc.identifierOE18IC2025
dc.identifier.doi10.1016/j.ijpddr.2024.100530
dc.identifier.eissn2211-3207
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.placePaíses Bajos
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/114
dc.identifier.urihttps://doi.org/10.1016/j.ijpddr.2024.100530
dc.language.isoeng
dc.publisherElsevier
dc.relation24, 100530
dc.relation.jnabreviadoINT J PARASITOL DRUGS DRUG RESIST
dc.relation.journalInternational Journal for Parasitology. Drugs and Drug Resistance.
dc.rightsAcceso Cerrado
dc.subject.kwAnti-Plasmodium
dc.subject.kwAntiplasmodial
dc.subject.kwAntiprotozoal
dc.subject.kwMalaria complex disease
dc.subject.kwParasites
dc.titleModified peptides and organic metabolites of cyanobacterial origin with antiplasmodial properties
dc.typeArticulo

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