Development of anxiolytic and depression-like behavior in mice infected with mycobacterium lepraemurium

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dc.contributor.affiliationDepartamento de Ciencias de la Salud, Centro Universitario de los Altos, Universidad de Guadalajara, Carretera a Yahualica, Km. 7.5 Tepatitlán de Morelos, Jalisco 47600, Mexico
dc.contributor.emailrojas_espinosa@hotmail.com (O. Rojas-Espinosa) ; lusenbeve@yahoo.com (E. Becerril-Villanueva)
dc.creatorPonce-Regalado, M. D.es_ES
dc.creatorSalazar-Juárez, A.es_ES
dc.creatorRojas-Espinosa, O.es_ES
dc.creatorContis-Montes de Oca, A.es_ES
dc.creatorHurtado-Alvarado, G.es_ES
dc.creatorArce-Paredes, P.es_ES
dc.creatorPérez-Sánchez, G.es_ES
dc.creatorPavón, L.es_ES
dc.creatorGirón-Pérez, M. I.es_ES
dc.creatorHernández-Pando, R.es_ES
dc.creatorAlvarez-Sánchez, M. E.es_ES
dc.creatorBecerril-Villanueva, Enriquees_ES
dc.date2022
dc.date.accessioned2024-12-19T17:57:48Z
dc.date.accessioned2026-03-27T15:30:56Z
dc.date.available2024-12-19T17:57:48Z
dc.date.issued2022
dc.date.published2022
dc.descriptionMurine leprosy is a systemic infectious disease of mice caused by Mycobacterium lepraemurium (MLM) in which the central nervous system (CNS) is not infected; nevertheless, diseased animals show measurable cognitive alterations. For this reason, in this study, we explored the neurobehavioral changes in mice chronically infected with MLM. BALB/c mice were infected with MLM, and 120 days later, the alterations in mice were evaluated based on immunologic, histologic, endocrine, neurochemical, and behavioral traits. We found increases in the levels of IL-4 and IL-10 associated with high bacillary loads. We also found increase in the serum levels of corticosterone, epinephrine, and norepinephrine in the adrenal gland, suggesting neuroendocrine deregulation. Mice exhibited depression-like behavior in the tail suspension and forced swimming tests and anxiolytic behavior in the open field and elevated plus maze tests. The neurobehavioral alterations of mice were correlated with the histologic damage in the prefrontal cortex, ventral hippocampus, and amygdala, as well as with a blood-brain barrier disruption in the hippocampus. These results reveal an interrelated response of the neuroimmune--endocrinological axis in unresolved chronic infections that result in neurocognitive deterioration.es_ES
dc.formatPDFes_ES
dc.identifierOE14IC22es_ES
dc.identifier.doi10.1016/j.neuroscience.2022.03.021
dc.identifier.eissn1873-7544
dc.identifier.issn0306-4522
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.placeEstados Unidos
dc.identifier.urihttps://doi.org/10.1016/j.neuroscience.2022.03.021
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/8169
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relation493:15-30
dc.relation.jnabreviadoNEUROSCIENCE
dc.relation.journalNeuroscience
dc.rightsAcceso Cerradoes_ES
dc.subject.kwAnxiolytic behavior
dc.subject.kwDepression-like behavior
dc.subject.kwChronic infection
dc.subject.kwCentral nervous system
dc.subject.kwMurine leprosy
dc.titleDevelopment of anxiolytic and depression-like behavior in mice infected with mycobacterium lepraemuriumes_ES
dc.typeArtículoes_ES

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