Glycine supplementation during six months does not alter insulin, glucose or triglyceride plasma levels in healthy rats

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dc.contributor.affiliationDepartment of Biochemistry, National Institute of Respiratory Diseases "Ismael Cosío Villegas", Mexico City, Mexico.
dc.contributor.emailnnooee@gmail.com (Noé Alvarado-Vásquez)
dc.creatorCerón, Eduardaes_ES
dc.creatorBernal-Alcántara, Demetrioes_ES
dc.creatorVanda, Beatrizes_ES
dc.creatorSommer, Bettinaes_ES
dc.creatorGonzalez-Trujano, Evaes_ES
dc.creatorAlvarado-Vásquez, Noées_ES
dc.creator.identificadorhttps://orcid.org/0000-0002-4399-1508 (González-Trujano, María Eva)
dc.date2021
dc.date.accessioned2023-07-27T14:50:36Z
dc.date.accessioned2026-03-27T15:26:18Z
dc.date.available2023-07-27T14:50:36Z
dc.date.issued2021
dc.date.published2021
dc.descriptionNowadays, glycine is used in nutritional supplements and to attenuate chronic complications of diabetes and obesity; however, its use has side effects as insulin resistance. Our aim was to evaluate the effect of chronic glycine supplementation on insulin, glucose and triglyceride levels in healthy Wistar rats. Groups were: Control (C), that received sterilized water only, glycine (GG), that received 1% glycine and taurine (TG), that received 0.5% taurine during 6 months (n = 10). Our results showed no differences in plasma insulin levels after six months of supplementation (C: 13.22 ± 2.0; GG: 11.4 ± 2.0; TG: 11.13 ± 2.0 ng/ml; p = 0.64). Likewise, neither glucose plasma concentration (C: 99.9 ± 3.9 mg/dl; GG: 104.3 ± 4.3 mg/dl; TG: 104.5 ± 4.8 mg/dl) (p = 0.88) nor triglyceride levels (C: 58.4 ± 5.6 mg/dl; GG: 46.9 ± 2.3 mg/dl; TG: 50.68 ± 3.3 mg/dl), showed differences after six months supplementation (p = 0.22). Furthermore, the analysis of glycine (C: 80 ± 24.6; GG: 83.9 ± 25.9; TG: 90.7 ± 13.5 nmol/ml) (p = 0.19) and taurine (C: 169 ± 15.17; GG: 148.7 ± 23.9; TG: 165.8 ± 22.5 nmol/ml) (p = 0.4) in the plasma of animals with supplementation showed no significant changes. Additionally, general urine tests and histological analysis of liver or kidneys showed no alterations. In conclusion, chronic supplementation with 1% glycine did not have any significant detrimental side effects in our model. However, more studies are still necessary to evaluate the effect of 1% glycine supplementation in humans.es_ES
dc.formatPDFes_ES
dc.identifierJC30NC20es_ES
dc.identifier.doi10.1024/0300-9831/a000645
dc.identifier.issn0300-9831
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.placeSuiza
dc.identifier.urihttps://doi.org/10.1024/0300-9831/a000645
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/7718
dc.language.isoenges_ES
dc.publisherHans Huberes_ES
dc.relation91(5-6) 451-460
dc.relation.jnabreviadoINT J VITAM NUTR RES
dc.relation.journalInternational Journal for Vitamin and Nutrition Research
dc.rightsAcceso Cerradoes_ES
dc.subject.kwAmino acid
dc.subject.kwGlucose
dc.subject.kwGlycine
dc.subject.kwInsulin
dc.subject.kwMetabolism
dc.subject.kwTaurine
dc.titleGlycine supplementation during six months does not alter insulin, glucose or triglyceride plasma levels in healthy ratses_ES
dc.typeArtículoes_ES

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