Antinociceptive synergy between metamizole and hesperidin in a model of visceral pain in mice

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dc.contributor.affiliationDepartamento de Farmacología, Facultad de Medicina, Universidad Nacional Autonoma de México, Ciudad de México, México
dc.contributor.emailrventuram7@hotmail.com ; rventuram@comunidad.unam.mx (Rosa Ventura-Martinez)
dc.creatorVentura-Martinez, Rosaes_ES
dc.creatorMares-Sánchez, José Jesúses_ES
dc.creatorAvilés-Herrera, Josées_ES
dc.creatorÁngeles-López, Guadalupe Estheres_ES
dc.creatorDéciga-Campos, Myrnaes_ES
dc.creatorGonzález-Trujano, María Evaes_ES
dc.creatorLópez-Muñoz, Francisco Javieres_ES
dc.date2021
dc.date.accessioned2024-06-21T17:35:03Z
dc.date.accessioned2026-03-27T15:30:13Z
dc.date.available2024-06-21T17:35:03Z
dc.date.issued2021
dc.date.published2021
dc.descriptionBackground: Metamizole is used to relieve the visceral pain but its adverse effects limit its use. An alternative to improve its efficacy with lower doses is to combine it with a natural product as hesperidin. Aim of the study: The aim of this study was to evaluate the antinociceptive interaction between metamizole and hesperidin in a visceral pain model using an isobolographic analysis. Methods: Antinociception was evaluated in the writhing model using acetic acid (1%) to induce writhes in mice. Metamizole (1-316 mg/kg), hesperidin (3-300 mg/kg), or combinations with a fixed-dose ratio of 1:1 were administered intraperitoneally 30 min before the acetic acid and the number of writhes was counted for 30 min. Isobolographic analysis was employed to define the nature of the compound interaction. Results: Metamizole and hesperidin in individual administration induced dose-dependent antinociceptive effects, reached an efficacy of 84.2 ± 5.9% and 66.3 ± 7.4%, respectively. The ED50 values calculated from their dose-response curves were 84.5 ± 22.7 and 108.9 ± 17.9 mg/kg, respectively. The analysis of DRC for the metamizole + hesperidin combination, in a ratio 1:1 showed a ED50 COMB value lower than the ED50 ADD estimated from the additivity line from the isobologram (46.7 ± 6.3 vs. 96.7 ± 11.9 mg/kg, respectively). In addition, the pharmacological interaction calculated was of 0.48. These results suggest a synergistic interaction for the antinociceptive activity of metamizole + hesperidin combination. Conclusion: These data suggest that metamizole + hesperidin combination could be useful in treating visceral pain as it can interact synergistically using low dose of both drugs with the possibility of reducing the risk of adverse effects.es_ES
dc.formatPDFes_ES
dc.identifierJC32NC21es_ES
dc.identifier.doi10.1016/j.arcmed.2020.12.011
dc.identifier.eissn1873-5487
dc.identifier.issn0188-4409
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.placeMéxico
dc.identifier.urihttps://doi.org/10.1016/j.arcmed.2020.12.011
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/8012
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relation52(4):389-396
dc.relation.jnabreviadoARCH MED RES
dc.relation.journalArchives of Medical Research
dc.rightsAcceso Cerradoes_ES
dc.subject.kwAntinociceptive interaction
dc.subject.kwMetamizole, Hesperidin
dc.subject.kwSynergistic interaction
dc.subject.kwIsobolographic analysis
dc.subject.kwWrithing test
dc.titleAntinociceptive synergy between metamizole and hesperidin in a model of visceral pain in micees_ES
dc.typeArtículoes_ES

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