Neuropharmacological profile of an ethanol extract of Ruta chalepensis L. in mice

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dc.contributor.affiliationDireccion de Investigaciones en Neurociencias del Instituto Nacional de Psiquiatria Ramon de la Fuente, Calz. Mexico-Xochimilco 101, Col. Sn Lorenzo Huipulco, 14370 Mexico, D.F., Mexicoes_ES
dc.contributor.emailevag@imp.edu.mxes_ES
dc.creatorGonzález-Trujano, M.E.
dc.creatorCarrera, D.
dc.creatorVentura-Martínez, R.
dc.creatorCedillo-Portugal, E.
dc.creatorNavarrete, A.
dc.creator.identificador"GOTE681027MMCNRV09">González Trujano, María Evaes_ES
dc.date.accessioned2017-06-30T01:33:49Z
dc.date.accessioned2026-03-27T14:46:59Z
dc.date.available2017-06-30T01:33:49Z
dc.date.issued2006es_ES
dc.date.published2006es_ES
dc.description.abstractotrodiomaThe effects of an ethanol extract of the aerial parts of Ruta chalepensis on the central nervous system (CNS) and LD(50) determination were studied in mice. A crude extract was given systemically and its effects were tested on pentylenetetrazole (PTZ)-induced seizures, sodium pentobarbital-induced hypnosis, exploratory activity, anxiety and nociception. Results from the experimental models tested showed: (1) a delay in the onset of seizures and a dose-dependent suppression in the tonic phase and mortality induced by PTZ; (2) a prolongation of the time of sodium pentobarbital-induced hypnosis; (3) a significant attenuation in the anxiety-response and (4) a reduction in the licking time and shaking behavior in the formalin-induced nociception test. The sedative-hypnotic potentiation, anxiolytic, anticonvulsant and antinociceptive effects suggest that Ruta chalepensis induces a depressant activity on the CNSes_ES
dc.description.monthJunes_ES
dc.identifier1463es_ES
dc.identifier.citationJuan Carlos Bautista Ramírezes_ES
dc.identifier.doi10.1016/j.jep.2005.12.014es_ES
dc.identifier.eissn1872-7573es_ES
dc.identifier.issn0378-8741es_ES
dc.identifier.numero1es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.paginacion129-135es_ES
dc.identifier.placeIrlandaes_ES
dc.identifier.urihttps://doi.org/10.1016/j.jep.2005.12.014es_ES
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/6144
dc.identifier.volumen106es_ES
dc.language.isoenges_ES
dc.relation106 (1) 129-135 p.es_ES
dc.relationversión del editores_ES
dc.relation.jnabreviadoJ ETHNOPHARMACOLes_ES
dc.relation.journalJournal of Ethnopharmacologyes_ES
dc.rightsacceso cerradoes_ES
dc.subject.koAnimalses_ES
dc.subject.koAnti-Anxiety Agentses_ES
dc.subject.kopharmacologyes_ES
dc.subject.koAnticonvulsantses_ES
dc.subject.kopharmacologyes_ES
dc.subject.koAnxietyes_ES
dc.subject.kochemically inducedes_ES
dc.subject.koAnxietyes_ES
dc.subject.kodrug therapyes_ES
dc.subject.koCentral Nervous System Depressantses_ES
dc.subject.kopharmacologyes_ES
dc.subject.koEthanoles_ES
dc.subject.kopharmacologyes_ES
dc.subject.koExploratory Behaviores_ES
dc.subject.kodrug effectses_ES
dc.subject.koHypnotics and Sedativeses_ES
dc.subject.kopharmacologyes_ES
dc.subject.koMalees_ES
dc.subject.koMicees_ES
dc.subject.koPain Measurementes_ES
dc.subject.koPentobarbitales_ES
dc.subject.kotoxicityes_ES
dc.subject.koPentylenetetrazolees_ES
dc.subject.kotoxicityes_ES
dc.subject.koPhytotherapyes_ES
dc.subject.koPlant Extractses_ES
dc.subject.kopharmacologyes_ES
dc.subject.koRutaes_ES
dc.subject.kochemistryes_ES
dc.subject.koSeizureses_ES
dc.subject.kochemically inducedes_ES
dc.subject.koSeizureses_ES
dc.subject.kodrug therapyes_ES
dc.subject.koAnti-Anxiety Agentses_ES
dc.subject.koAnticonvulsantses_ES
dc.subject.koCentral Nervous System Depressantses_ES
dc.subject.koHypnotics and Sedativeses_ES
dc.subject.koPlant Extractses_ES
dc.subject.koPentylenetetrazolees_ES
dc.subject.koEthanoles_ES
dc.subject.koPentobarbitales_ES
dc.titleNeuropharmacological profile of an ethanol extract of Ruta chalepensis L. in micees_ES
dc.typearticlees_ES

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