Increased Leptin Levels in Plasma and Serum in Patients with Metabolic Disorders: A Systematic Review and Meta-Analysis

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dc.contributor.affiliationDivisión Académica Multidisciplinaria de Jalpa de Méndez, Universidad Juárez Autónoma de Tabasco, Jalpa de Méndez 86205, Tabasco, Mexico.
dc.creatorHernández-Díaz, Yazmín
dc.creatorOvando-Almeida, María de Los Ángeles
dc.creatorFresán, Ana
dc.creatorJuárez-Rojop, Isela Esther
dc.creatorGenis-Mendoza, Alma Delia
dc.creatorNicolini, Humberto
dc.creatorGonzález-Castro, Thelma Beatriz
dc.creatorTovilla-Zárate, Carlos-Alfonso
dc.creatorLópez-Narváez, María Lilia
dc.date2024
dc.date.accessioned2026-06-12T20:00:16Z
dc.date.issued2024
dc.date.published2024
dc.descriptionA large number of studies have reported the relationships between leptin levels and diabetes or obesity. However, the results are still controversial, and no consensus has been reached. Therefore, the purpose of the study was to collect data from various databases to perform a meta-analysis and address the inconsistencies in these studies. A systematic literature search was conducted on PubMed, Web of Science, and EBSCO for relevant available articles. The pooled standard mean difference (SMD) with 95% confidence interval (CI) was used to estimate the association by a meta-analysis. Fifteen reports with 1,388 cases and 3,536 controls were chosen for the meta-analysis. First, an increase in leptin levels in serum (SMD 0.69; 95% CI 0.36-1.02 ng/mL) and plasma (SMD 0.46; 95% CI 0.18-0.74 ng/mL) was observed in individuals with diabetes compared to controls. This increased level was also observed by gender and population. Second, statistical analysis showed that leptin levels in serum were significantly increased in individuals with obesity (SMD 1.03; 95% CI 0.72-1.34 ng/mL). This meta-analysis analyzed leptin in individuals with diabetes or obesity and emphasized the importance of monitoring serum/plasma leptin levels in patients with these diseases. However, more comprehensive studies are necessary in order to draw firm conclusions.
dc.formatPDF
dc.identifierOE13IC2025
dc.identifier.doi10.3390/ijms252312668
dc.identifier.eissn1422-0067
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.placeSuiza
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/92
dc.identifier.urihttps://doi.org/10.3390/ijms252312668
dc.language.isoeng
dc.publisherMDPI
dc.relation26;25(23):12668.
dc.relation.jnabreviadoINT J MOL SCI
dc.relation.journalInternational Journal of Molecular Sciences
dc.rightsAcceso Cerrado
dc.subject.kwChronic diseases
dc.subject.kwDiabetes
dc.subject.kwLeptin
dc.subject.kwMeta-analysis
dc.subject.kwMetabolism
dc.subject.kwObesity
dc.titleIncreased Leptin Levels in Plasma and Serum in Patients with Metabolic Disorders: A Systematic Review and Meta-Analysis
dc.typeArticulo

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