Association analysis of TPH-1 and TPH-2 genes with suicidal behavior in patients with attempted suicide in Mexican population

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dc.contributor.affiliationHospital General de Yajalón, Secretaria de Salud, Yajalón, Chiapas, México
dc.contributor.emaildralilialonar@yahoo.com.mx, (M.L. López-Narváez), alfonso_tovillaz@yahoo.com.mx, (C.A. Tovilla-Zárate), thelma.glez.castro@gmail.com, (T.B. González-Castro), iselajua22@yahoo.com.mx (I. Juárez-Rojop), shepoga70@hotmail.com (S. Pool-García), genis76@yahoo.com (A. Genis), jblecastillo@hotmail.com (J.L. Ble-Castillo), fresan@imp.edu.mx (A. Fresán)
dc.creatorLópez-Narváez, María Liliaes_ES
dc.creatorTovilla-Zárate, Carlos Alfonsoes_ES
dc.creatorGonzález-Castro, Thelma Beatrizes_ES
dc.creatorJuárez-Rojop, Iselaes_ES
dc.creatorPool-García, Sherezadaes_ES
dc.creatorGenis, Almaes_ES
dc.creatorBle-Castillo, Jorge L.es_ES
dc.creatorFresán, Anaes_ES
dc.date2015
dc.date.accessioned2025-10-21T19:34:57Z
dc.date.accessioned2026-03-27T15:33:20Z
dc.date.available2025-10-21T19:34:57Z
dc.date.issued2015
dc.date.published2015
dc.descriptionBackground: Suicidal behavior is a worldwide health problem. Tryptophan hydroxylase (TPH) is a rate limiting enzyme in the biosynthesis of serotonergic neurotransmission. TPH-1 and TPH-2 genes encode for TPH isoforms and have been implicated as candidate genes for suicidal behavior. The aim of this study was to evaluate the association between the genetic variants of the TPH-1 (rs21102 and 1607395) and TPH-2 (rs4290270, rs7305115 and rs1007023) genes and suicidal behavior in a Mexican population. Methods: We conducted a case-control study including 200 cases with suicide attempt and 263 controls. Patients were evaluated by a trained psychiatrist or clinical psychologists. Five polymorphisms were genotyped and assessed for allele, genotype and haplotype association with suicide attempt. Results: The rs7305115 polymorphism of the TPH-2 gene was associated with suicidal behavior in a Mexican population in genotype (χ(2)=6.02, df=2, p=0.04) and allele (OR=1.39, 95%IC=1.06-1.81, p=0.01) frequencies. The THP-2 haplotypes GTA (χ(2)=5.68, p=0.01) and ATT (χ(2)=5.0, p=0.02) were associated with risk for suicide attempt. Conclusion: Our results provide evidence for an association between the rs7305115 polymorphism of the TPH-2 gene and suicidal behavior in a Mexican population. However, more studies are necessary to replicate these results using larger samples.es_ES
dc.formatPDFes_ES
dc.identifier.doi10.1016/j.comppsych.2015.05.002
dc.identifier.eissn1532-8384
dc.identifier.issn0010-440X
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.placeEstados Unidos
dc.identifier.urihttps://doi.org/10.1016/j.comppsych.2015.05.002
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/8470
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relation61:72-77
dc.relation.jnabreviadoCOMPR PSYCHIATRY
dc.relation.journalComprehensive Psychiatry
dc.rightsAcceso Cerradoes_ES
dc.titleAssociation analysis of TPH-1 and TPH-2 genes with suicidal behavior in patients with attempted suicide in Mexican populationes_ES
dc.typeArtículoes_ES

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