Anti-ulcer activity of Cyrtocarpa procera analogous to that of Amphipterygium adstringens, both assayed on the experimental gastric injury in rats

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dc.contributor.affiliationFacultad de Estudios Superiores "Zaragoza", Universidad Nacional Autónoma de México, J.C. Bonilla 66 y Calzada Ignacio Zaragoza, Col. Ejército de Oriente, Iztapalapa 09230, México, D.F., Mexico.es_ES
dc.contributor.emailevag@imp.edu.mxes_ES
dc.creatorRosas-Acevedo, Hortensia
dc.creatorTerrazas, Teresa
dc.creatorGonzález-Trujano, M. Eva
dc.creatorGuzmán, Yolanda
dc.creatorSoto-Hernández, Marcos
dc.date.accessioned2017-06-30T01:40:43Z
dc.date.accessioned2026-03-27T14:47:07Z
dc.date.available2017-06-30T01:40:43Z
dc.date.issued2011es_ES
dc.date.published2011es_ES
dc.description.abstractotrodiomaETHNOPHARMACOLOGICAL RELEVANCE: The bark of Amphipterygium adstringens (Aa) is commonly mixed or adulterated with the bark of Cyrtocarpa procera (Cp) and sold in Mexican markets. Aa is a well known species in Mexico used as decoction to relieve ulcers. Scientific reports reinforcing the anti-ulcer activity of Aa have been previously described, but those describing the anti-ulcer properties of Cp as a substitute for Aa in folk medicine are scarce. AIM OF THE STUDY: To investigate anatomical and phytochemical differences between these species, as well as to assess the anti-ulcer effect of Cp extracts in comparison to the Aa extracts. MATERIAL AND METHODS: Anatomical micro-technique and physical and spectroscopic data were used to analyze differences between Cp and Aa. Regard to the pharmacological activity, it was assessed by using the ethanol-induced gastric damage model in rats. RESULTS: Whereas the bark anatomy of Aa was characterized by vertical canals in the periderm and the rare occurrence of fibers in its phloem, a periderm without vertical canals and abundant fibers in the phloem were distinctive features of Cp. Phytochemical analysis allowed the identification of tirucallane, masticadienonic and 3_-hydroxymasticadienonic acids as major components in Aa, while _-amyrin and _-sitosterol were obtained from Cp. Gastric lesions observed in the control group decreased in the presence of 100mg-kg of hexane, ethyl acetate and methanol extracts from the normal or regenerated bark of Cp, thus resembling the anti-ulcer effect of Aa. Nevertheless, major anti-ulcer potency was observed with the most active methanol extract from Cp obtained from normal [the effective dose fifty ED(50)=45.54 mg-kg] or regenerated (ED(50)=36.68 mg-kg) bark in comparison to Aa (ED(50)=115.64 mg-kg). CONCLUSION: Chemical and anatomical differences were found between these species, but since the anti-ulcer activity of Cp is similar to that shown by Aa our results reinforce the use of both species for the relief of gastric ulcer in folk medicinees_ES
dc.description.monthMares_ES
dc.identifier1516es_ES
dc.identifier.citationJuan Carlos Bautista Ramírezes_ES
dc.identifier.doi10.1016/j.jep.2010.11.057es_ES
dc.identifier.eissn1872-7573es_ES
dc.identifier.issn0378-8741es_ES
dc.identifier.numero1es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.paginacion67-73es_ES
dc.identifier.placeIrlandaes_ES
dc.identifier.urihttps://doi.org/10.1016/j.jep.2010.11.057es_ES
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/6195
dc.identifier.volumen134es_ES
dc.language.isoenges_ES
dc.relation134 (1) 67-73 p.es_ES
dc.relationversión del editores_ES
dc.relation.jnabreviadoJ ETHNOPHARMACOLes_ES
dc.relation.journalJournal of Ethnopharmacologyes_ES
dc.rightsacceso cerradoes_ES
dc.subject.koAnacardiaceaees_ES
dc.subject.kochemistryes_ES
dc.subject.koAnimalses_ES
dc.subject.koAnti-Ulcer Agentses_ES
dc.subject.kopharmacologyes_ES
dc.subject.koAnti-Ulcer Agentses_ES
dc.subject.kotherapeutic usees_ES
dc.subject.koGastric Mucosaes_ES
dc.subject.kodrug effectses_ES
dc.subject.koPlant Extractses_ES
dc.subject.kopharmacologyes_ES
dc.subject.koPlant Extractses_ES
dc.subject.kotherapeutic usees_ES
dc.subject.koRatses_ES
dc.subject.koAnti-Ulcer Agentses_ES
dc.subject.koPlant Extractses_ES
dc.titleAnti-ulcer activity of Cyrtocarpa procera analogous to that of Amphipterygium adstringens, both assayed on the experimental gastric injury in ratses_ES
dc.typearticlees_ES

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