Anxiety-like Behavior and GABAAR/BDZ Binding Site Response to Progesterone Withdrawal in a Stress-Vulnerable Strain, the Wistar Kyoto Rats

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dc.contributor.affiliationLab de Neuropsicofarmacología, Dirección de Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Ciudad de México 14370, Mexico
dc.contributor.emailestrada@imp.edu.mx (E.E.-C.); clopezr@cinvestav.mx (C.L.-R.)
dc.creatorIslas-Preciado, Danniaes_ES
dc.creatorUgalde-Fuentes, Gabrielaes_ES
dc.creatorSollozo-Dupont, Isabeles_ES
dc.creatorGonzález Trujano, María Evaes_ES
dc.creatorCervantes-Anaya, Nancyes_ES
dc.creatorEstrada-Camarena, Erikaes_ES
dc.creatorLópez-Rubalcava, Carolinaes_ES
dc.creator.identificadorhttps://orcid.org/0000-0002-4569-3643 (Sollozo-Dupont, Isabel)
dc.creator.identificadorhttps://orcid.org/0000-0002-4399-1508 (González Trujano, María Eva)
dc.creator.identificadorhttps://orcid.org/0000-0001-6634-7494 (Estrada-Camarena, Erika)
dc.date2022
dc.date.accessioned2024-12-09T18:49:32Z
dc.date.accessioned2026-03-27T15:30:45Z
dc.date.available2024-12-09T18:49:32Z
dc.date.issued2022
dc.date.published2022
dc.descriptionStress susceptibility could play a role in developing premenstrual anxiety due to abnormalities in the hypothalamus-pituitary-adrenal (HPA) axis and impairments in the GABAA receptors' benzodiazepine (BDZ) site. Hence, we studied the stress-vulnerable Wistar Kyoto rat strain (WKY) to evaluate progesterone withdrawal (PW) effects on anxiety, HPA axis response, and to explore indicators of GABAA functionality in the BDZ site. For five days, ovariectomized WKY rats were administered 2.0 mg/kg of progesterone. Twenty-four hours after the last administration, rats were tested in the anxiety-like burying behavior test (BBT) or elevated plus maze test (EPM), and corticosterone was determined. [3H]Flunitrazepam binding autoradiography served as the BDZ binding site index of the GABAA receptor in amygdala nuclei and hippocampus's dentate gyrus (DG). Finally, different doses of diazepam in PW-WKY rats were tested in the BBT. PW induced anxiety-like behaviors in both BBT and EPM compared with No-PW rats. PW increased corticosterone, but was blunted when combined with PW and BBT. PW increased [3H]Flunitrazepam binding in the DG and central amygdala compared with No-PW rats. Diazepam at a low dose induced an anxiogenic-like response in PW rats, suggesting a paradoxical response to benzodiazepines. Overall, PW induced anxiety-like behavior, a blunted HPA axis response, and higher GABAAR/BZD binding site sensitivity in a stress-vulnerable rat strain. These findings demonstrate the role of stress-susceptibility in GABAAR functionality in a preclinical approximation of PMDD.es_ES
dc.formatPDFes_ES
dc.identifierJC07NC22es_ES
dc.identifier.doi10.3390/ijms23137259
dc.identifier.eissn1422-0067
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.placeSuiza
dc.identifier.urihttps://doi.org/10.3390/ijms23137259
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/8146
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.relation23(13):7259
dc.relation.jnabreviadoINT J MOL SCI
dc.relation.journalInternational Journal of Molecular Sciences
dc.rightsAcceso Cerradoes_ES
dc.subject.kwAnxiety-like behavior
dc.subject.kwProgesterone withdrawal
dc.subject.kwBDZ site in the GABAA receptor
dc.subject.kwHPA axis function
dc.titleAnxiety-like Behavior and GABAAR/BDZ Binding Site Response to Progesterone Withdrawal in a Stress-Vulnerable Strain, the Wistar Kyoto Ratses_ES
dc.typeArtículoes_ES

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