5 Hz of repetitive transcranial magnetic stimulation improves cognition and induces modifications in hippocampal neurogenesis in adult female Swiss Webster mice

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dc.contributor.affiliationLaboratorio de Neurogénesis, Subdirección de Investigaciones Clínicas, Instituto Nacional de Psiquiatría "Ramón de la Fuente Muñiz", Calzada México-Xochimilco 101, 14370 Ciudad de México, Mexico
dc.contributor.editorgbernabe@imp.edu.mx (G.B. Ramírez-Rodríguez) ; david.msj@imp.edu.mx (D.M.-S. Juan) ; jjgonz@imp.edu.mx (J.J. González-Olvera)
dc.creatorRamírez-Rodríguez, Gerardo Bernabées_ES
dc.creatorMeneses-San Juan, Davides_ES
dc.creatorGonzález-Olvera, Jorge Julioes_ES
dc.date2022
dc.date.accessioned2024-12-12T15:33:32Z
dc.date.accessioned2026-03-27T15:30:54Z
dc.date.available2024-12-12T15:33:32Z
dc.date.issued2022
dc.date.published2022
dc.descriptionAdult hippocampal neurogenesis is regulated by several stimuli to promote the creation of a reserve that may facilitate coping with environmental challenges. In this regard, repetitive transcranial magnetic stimulation (rTMS), a neuromodulation therapy, came to our attention because in clinical studies it reverts behavioral and cognitive alterations related to changes in brain plasticity. Some preclinical studies emphasize the need to understand the underlying mechanism of rTMS to induce behavioral modifications. In this study, we investigated the effects of rTMS on cognition, neurogenic-associated modifications, and neuronal activation in the hippocampus of female Swiss Webster mice. We applied 5 Hz of rTMS twice a day for 14 days. Three days later, mice were exposed to the behavioral battery. Then, brains were collected and immunostained for Ki67-positive cells, doublecortin-positive (DCX+)-cells, calbindin, c-Fos and FosB/Delta-FosB in the dentate gyrus. Also, we analyzed mossy fibers and CA3 with calbindin immunostaining. Mice exposed to rTMS exhibited cognitive improvement, an increased number of proliferative cells, DCX cells, DCX cells with complex dendrite morphology, c-Fos and immunoreactivity of FosB/Delta-FosB in the granular cell layer. The volume of the granular cell layer, mossy fibers and CA3 in rTMS mice also increased. Interestingly, cognitive improvement correlated with DCX cells with complex dendrite morphology. Also, those DCX cells and calbindin immunoreactivity correlated with c-Fos in the granular cell layer. Our results suggest that 5 Hz of rTMS applied twice a day modify cell proliferation, doublecortin cells, mossy fibers and enhance cognitive behavior in healthy female Swiss Webster mice.es_ES
dc.formatPDFes_ES
dc.identifierOE12IC22es_ES
dc.identifier.doi10.1016/j.brainresbull.2022.06.001
dc.identifier.eissn1873-2747
dc.identifier.issn0361-9230
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.placeEstados Unidos
dc.identifier.urihttps://doi.org/10.1016/j.brainresbull.2022.06.001
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/8158
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relation186:91-105
dc.relation.jnabreviadoBRAIN RES BULL
dc.relation.journalBrain Research Bulletin
dc.rightsAcceso Cerradoes_ES
dc.subject.kwAdult neurogenesis
dc.subject.kwC-Fos
dc.subject.kwCalbindin
dc.subject.kwCognition
dc.subject.kwDelta-FosB
dc.subject.kwDoublecortin
dc.subject.kwHippocampus
dc.subject.kwMicroglia
dc.subject.kwRepetitive transcranial magnetic stimulation
dc.title5 Hz of repetitive transcranial magnetic stimulation improves cognition and induces modifications in hippocampal neurogenesis in adult female Swiss Webster micees_ES
dc.typeArtículoes_ES

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