Sleep deprivation induces changes in immunity in Trichinella spiralis-infected rats

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dc.contributor.affiliationDepartamento de Inmunología, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, AP 70228, México D.F. 04510, México
dc.contributor.emailjmontor66@biomedicas.unam.mx ; jmontor66@hotmail.com (Jorge Morales Montor)
dc.creatorIbarra-Coronado, Elizabeth G.es_ES
dc.creatorVelazquéz-Moctezuma, Javieres_ES
dc.creatorDiaz, Danieles_ES
dc.creatorBecerril-Villanueva, Luis Enriquees_ES
dc.creatorPavón, Lenines_ES
dc.creatorMorales-Montor, Jorgees_ES
dc.date2015
dc.date.accessioned2025-09-11T20:22:09Z
dc.date.accessioned2026-03-27T15:32:38Z
dc.date.available2025-09-11T20:22:09Z
dc.date.issued2015
dc.date.published2015
dc.descriptionSleep is considered an important predictor of immunity. A lack of sleep may reduce immunity, which increases susceptibility to any type of infection. Moreover, sleep deprivation in humans produces changes in both, the percent of circulating immune cells (T cells and NK cells) and cytokine levels (IL-1, IFNγ, TNΦ-αα, IL-6 and IL-17). The aim of our study was to investigate whether sleep deprivation produces deregulation on immune variables during the immune response generated against the helminth parasite Trichinella spiralis. Because sleep deprivation is stressful per se, we designed another experiments to compared stress alone (consisting in movement restriction and single housing) with sleep deprivation, in both control (uninfected) and experimental (infected) rats. Our results demonstrate that the sleep deprivation and stress have a differential effect in mesenteric lymph nodes (MLN) and spleen. In uninfected rats sleep deprivation alone produces an increase in natural killer cells (NK+) and B cells (CD45+), accompanied by a decrease in cytotoxic T cells (CD3+CD8+) in spleen; while, in MLN, produces only an increase in natural killer cells (NK+). Both, SD and stress, produce an increased percentage of total T cells (CD3+) in spleen. In the MLN both are also associated to an increase in cytotoxic T cells (CD3+CD8+) and B cells (CD45+). In the spleens of parasitized rats, cell populations did not change. In spleens of both, sleep-deprived and stressed infected rats, we observed an increase in B cells (CD45+). In infected rats, sleep deprivation alone produced an increase in NK cells (NK+). In mesenteric node cell populations of parasitized rats, we observed a decrease in NK cells and an increase in T helper (CD4+) cells in both SD and stressed rats. Rats that were only subjected to stress showed a decrease in B cells (CD45+). These findings suggest that the immune response generated against infection caused by T. spiralis is affected when the sleep pattern is disrupted. These results support the notion that sleep is a fundamental process for an adequate and strong immune response generated against this parasite.es_ES
dc.formatPDFes_ES
dc.identifier.doi10.7150/ijbs.11907
dc.identifier.eissn1449-2288
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.placeAustralia
dc.identifier.urihttp://doi.org/10.7150/ijbs.11907
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/8414
dc.language.isoenges_ES
dc.publisherIvyspring Internationales_ES
dc.relation11(8):901-912
dc.relation.jnabreviadoINT J BIOL SCI
dc.relation.journalInternational Journal of Biological Sciences
dc.rightsAcceso Cerradoes_ES
dc.subject.kwSleep deprivation
dc.subject.kwImmune response
dc.subject.kwParasite
dc.subject.kwTrichinella spiralis
dc.titleSleep deprivation induces changes in immunity in Trichinella spiralis-infected ratses_ES
dc.typeArtículoes_ES

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