The neurogenic effects of an enriched environment and its protection against the behavioral consequences of chronic mild stress persistent after enrichment cessation in six-month-old female Balb/C mice

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dc.contributor.affiliationLaboratory of Neuropsychopharmacology, Division of Neurosciences, National Institute of Psychiatry "Ramón de la Fuente Muñiz", Calz. México-Xochimilco 101, 14370 México, D.F., Mexico
dc.contributor.emailestrada@imp.edu.mx (E.M. Estrada-Camarena), gbernabe@imp.edu.mx (G.B. Ramírez-Rodríguez)
dc.creatorVega-Rivera, Nelly Maritzaes_ES
dc.creatorOrtiz-López, Leonardoes_ES
dc.creatorGómez-Sánchez, Ariadnaes_ES
dc.creatorOikawa-Sala, Julianes_ES
dc.creatorEstrada-Camarena, Erika Monserrates_ES
dc.creatorRamírez-Rodríguez, Gerardo Bernabées_ES
dc.date2016
dc.date.accessioned2025-10-22T18:39:38Z
dc.date.accessioned2026-03-27T15:33:22Z
dc.date.available2025-10-22T18:39:38Z
dc.date.issued2016
dc.date.published2016
dc.descriptionBecause stress may underlie the presence of depressive episodes, strategies to produce protection against or to reverse the effects of stress on neuroplasticity and behavior are relevant. Preclinical studies showed that exposure to stimuli, such as physical activity and environmental enrichment (ENR), produce beneficial effects against stress causing antidepressant-like effects in rodents. Additionally, ENR induces positive effects on neuroplasticity, neurochemistry and behavior at any age of rodents tested. Here, we analyzed whether ENR exposure prevents the development of depressive-like behavior produced by unpredictable, chronic mild stress (CMS) exposure as well as changes in hippocampal neurogenesis in a six-month-old female Balb/C mice, strain that shows low baseline levels of hippocampal neurogenesis. Mice were assigned to one of four groups: (1) normal housing-normal housing (NH-NH), (2) NH-CMS, (3) ENR-NH, or (4) ENR-CMS. The animals were exposed over 46 days to ENR or NH and subsequently to NH or CMS for 4 weeks. ENR induces long-term effects protecting against CMS induction of anhedonia and hopelessness behaviors. Independent of housing conditions, ENR increased the number of proliferative cells (Ki67), and CMS decreased the number of proliferative cells. ENR increased the newborn cells (BrdU) and mature phenotypes of neurons; these effects were not changed by CMS exposure. Similarly, the number of doublecortin-positive cells was not affected by CMS in ENR mice, which showed more cells with complex dendrite arborizations. Our study suggests that ENR induces protection against the effects of CMS on behavior and neuroplasticity in six-month-old Balb/C mice.es_ES
dc.formatPDFes_ES
dc.identifier.doi10.1016/j.bbr.2015.12.028
dc.identifier.eissn1872-7549
dc.identifier.issn0166-4328
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.urihttp://dx.doi.org/10.1016/j.bbr.2015.12.028
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/8474
dc.language.isoenges_ES
dc.publisherPaíses Bajoses_ES
dc.relation301:72-83
dc.relation.jnabreviadoBEHAV BRAIN RES
dc.relation.journalBehavioural Brain Research
dc.rightsAcceso Cerradoes_ES
dc.subject.kwChronic mild stress
dc.subject.kwAdult neurogenesis
dc.subject.kwHippocampus
dc.subject.kwCorticosterone
dc.subject.kwDoublecortin
dc.subject.kwDepression
dc.titleThe neurogenic effects of an enriched environment and its protection against the behavioral consequences of chronic mild stress persistent after enrichment cessation in six-month-old female Balb/C micees_ES
dc.typeArtículoes_ES

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