Upregulation of S100A8 in peripheral blood mononuclear cells from patients with depression treated with SSRIs: a pilot study

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dc.contributor.affiliationLaboratorio de Psicoinmunología, Instituto Nacional de Psiquiatría Ramón de La Fuente Muñiz, Colonia San Lorenzo Huipulco, Calzada México-Xochimilco 101, Tlalpan, 14370, Ciudad de Mexico, México
dc.contributor.emailszamudio@ipn.mx (Sergio Roberto Zamudio), gilberto.perez.sanchez@imp.edu.mx (Gilberto Pérez‑Sánchez)
dc.creatorGamboa-Sánchez, Concepciónes_ES
dc.creatorBecerril-Villanueva, Enriquees_ES
dc.creatorAlvarez-Herrera, Samanthaes_ES
dc.creatorLeyva-Mascareño, Gabrielaes_ES
dc.creatorGonzález-López, Sandra L.es_ES
dc.creatorEstudillo, Enriquees_ES
dc.creatorFernández-Molina, Alberto E.es_ES
dc.creatorElizalde-Contreras, José Migueles_ES
dc.creatorRuiz-May, Elieles_ES
dc.creatorSegura-Cabrera, Aldoes_ES
dc.creatorJiménez-Genchi, Janethes_ES
dc.creatorPavón, Lenines_ES
dc.creatorZamudio, Sergio Robertoes_ES
dc.creatorPérez-Sánchez, Gilbertoes_ES
dc.date2023
dc.date.accessioned2025-04-28T16:38:20Z
dc.date.accessioned2026-03-27T15:31:52Z
dc.date.available2025-04-28T16:38:20Z
dc.date.issued2023
dc.date.published2023
dc.descriptionBackground: Major depressive disorder (MDD) affects more than 350 million people worldwide, and there is currently no laboratory test to diagnose it. This pilot study aimed to identify potential biomarkers in peripheral blood mononuclear cells (PBMCs) from MDD patients. Methods: We used tandem mass tagging coupled to synchronous precursor selection (mass spectrometry) to obtain the differential proteomic profile from a pool of PBMCs from MDD patients and healthy subjects, and quantitative PCR to assess gene expression of differentially expressed proteins (DEPs) of our interest. Results: We identified 247 proteins, of which 133 had a fold change ≥ 2.0 compared to healthy volunteers. Using pathway enrichment analysis, we found that some processes, such as platelet degranulation, coagulation, and the inflammatory response, are perturbed in MDD patients. The gene-disease association analysis showed that molecular alterations in PBMCs from MDD patients are associated with cerebral ischemia, vascular disease, thrombosis, acute coronary syndrome, and myocardial ischemia, in addition to other conditions such as inflammation and diabetic retinopathy. Conclusions: We confirmed by qRT-PCR that S100A8 is upregulated in PBMCs from MDD patients and thus could be an emerging biomarker of this disorder. This report lays the groundwork for future studies in a broader and more diverse population and contributes to a deeper characterization of MDD.es_ES
dc.formatPDFes_ES
dc.identifierJC31NC23es_ES
dc.identifier.doi10.1186/s12953-023-00224-7
dc.identifier.eissn1477-5956
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.placeInglaterra
dc.identifier.urihttps://doi.org/10.1186/s12953-023-00224-7
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/8326
dc.language.isoenges_ES
dc.publisherBioMed Centrales_ES
dc.relation21(1):23
dc.relation.jnabreviadoPROTEOME SCI
dc.relation.journalProteome science
dc.rightsAcceso Cerradoes_ES
dc.subject.kwDepression
dc.subject.kwBiomarkers
dc.subject.kwS100A8
dc.titleUpregulation of S100A8 in peripheral blood mononuclear cells from patients with depression treated with SSRIs: a pilot studyes_ES
dc.typeArtículoes_ES

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