Effect of combined treatment of selective serotonin reuptake inhibitors plus immunomodulator on circulating cytokines levels in patients with major depressive disorder along 52 weeks of follow up 

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dc.contributor.affiliationInstituto Nacional de Psiquiatria Mexico, Laboratorio de Psicoinmunol, Mexico City, DF, Mexicoes_ES
dc.creatorPavon, Lenin
dc.creatorEugenia Hernandez, Maria
dc.creatorMayra Perez-Tapia, Sonia
dc.creatorMendieta, Danelia
dc.creatorBojalil, Rafael
dc.creatorEstrada-Garcia, Iris
dc.creatorEstrada-Parra, Sergio
dc.creator.identificadorhttp://orcid.org/0000-0002-6067-6868>Pavon, Lenines_ES
dc.creator.identificadorHEGE630202MDFRTG02>Hernandez, Maria Eugeniaes_ES
dc.date.accessioned2017-06-29T03:46:35Z
dc.date.accessioned2026-03-27T14:32:46Z
dc.date.available2017-06-29T03:46:35Z
dc.date.issued2013es_ES
dc.date.published2013es_ES
dc.description.abstractotrodiomaMajor depressive disorder (MDD) is a psychiatric illness that presents as a deficit of serotonergic eurotransmission in the central nervous system. MDD patients also experience alterations in cortisol and cytokines levels. Treatment with selective serotonin reuptake inhibitors (SSRIs) is the first-line antidepressant regimen for MDD. The aim of this study was to determine the effect of a combination of SSRIs and an immunomodulator—human dialyzable leukocyte extract (hDLE)—on cortisol and cytokines levels. Patients received SSRIs or SSRIs plus hDLE.The proinflammatory cytokines IL-1훽, IL-2, and IFN-훾; anti-inflammatory cytokines IL-13 and IL-10; and 24-h urine cortisol weremeasured at weeks (W) 0, 5, 20, 36, and 52 of treatment.Thereduction in cortisol levels in the SSRI-treated group was 30% until W52, in contrast, the combined treatment induced a 54% decrease at W36. The decline in cortisol in patients who were treated with SSRI plus hDLE correlated with reduction of anti-inflammatory cytokines and increases levels of proinflammatory cytokines at the study conclusion. These results suggest that the immune-stimulating activity of hDLE, in combination with SSRIs, restored the pro- and anti-inflammatory cytokine balance and cortisol levels in depressed patients versus those who were given SSRIs alone.es_ES
dc.description.monthSepes_ES
dc.identifier2663es_ES
dc.identifier.citationMaría Guadalupe Camal Ibáñezes_ES
dc.identifier.doi10.1155/2013/267871es_ES
dc.identifier.eissn1740-2530es_ES
dc.identifier.issn1740-2522es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.paginacion1-12es_ES
dc.identifier.placeNew Yorkes_ES
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/4512
dc.language.isoenges_ES
dc.publisherHindawi Publishing Corporation, 410 Park Avenue, 15TH Floor, #287 PMB, New York, NY 10022 USA es_ES
dc.relation1-12p.es_ES
dc.relationversión del editores_ES
dc.relation.jnabreviadoCLIN DEV IMMUNOLes_ES
dc.relation.journalClinical & developmental immunologyes_ES
dc.rightsacceso cerradoes_ES
dc.titleEffect of combined treatment of selective serotonin reuptake inhibitors plus immunomodulator on circulating cytokines levels in patients with major depressive disorder along 52 weeks of follow up es_ES
dc.typeartículoes_ES

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