Transcranial focal electrical stimulation reduces seizure activity and hippocampal glutamate release during status epilepticus

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dc.contributor.affiliationDept. of Pharmacobiology, Center for Research and Advanced Studies, Mexico City, Mexico
dc.contributor.emailbesio@uri.edu
dc.creatorSantana-Gómez, César E.es_ES
dc.creatorAlcántara-González, Davides_ES
dc.creatorLuna-Munguia, Hirames_ES
dc.creatorBañuelos-Cabrera, Ivettees_ES
dc.creatorMagdaleno-Madrigal, Víctores_ES
dc.creatorTamayo, Michaeles_ES
dc.creatorRocha, Luisa L.es_ES
dc.creatorBesio, Walter G.es_ES
dc.date2015
dc.date.accessioned2025-09-25T20:25:49Z
dc.date.accessioned2026-03-27T15:32:42Z
dc.date.available2025-09-25T20:25:49Z
dc.date.issued2015
dc.date.published2015
dc.descriptionPreviously we demonstrated that noninvasive transcranial focal electrical stimulation (TFS) with sub-effective doses of diazepam reduces status epilepticus (SE)-induced neuronal damage. However, it was unclear if this neuroprotective effect is a consequence of the decrease in the glutamate release. The aim of the present study was to evaluate the effects of TFS on γ-Aminobutyric acid (GABA) and glutamate release in the hippocampus during pilocarpine-induced SE. After pilocarpine administration, the rats showed progressive behavioral changes that culminated in SE with a significant increase of GABA and glutamate (95 and 128% respectively), even more evident at the end of the experiment (120 and 182% respectively), 5 hours after pilocarpine injection and was associated with the prevalence of high-voltage rhythmic spikes and increased spectral power in the 4-90 Hz bands. The TFS application during the SE decreased the convulsive expression, the prevalence of high-voltage rhythmic spikes and spectral power in 4-8 Hz and 30-90 Hz bands. These effects were associated with lower release of GABA and glutamate in the hippocampus. These results support the anticonvulsive and neuroprotective effects induced by TFS.es_ES
dc.formatPDFes_ES
dc.identifier.doi10.1109/EMBC.2015.7319902
dc.identifier.eissn2694-0604
dc.identifier.issn2375-7477
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.placeEstados Unidos
dc.identifier.urihttp://doi.org/10.1109/EMBC.2015.7319902
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/8424
dc.language.isoenges_ES
dc.publisherIEEEes_ES
dc.relation2015:6586-6589
dc.relation.jnabreviadoANNU INT CONF IEEE ENG MED BIOL SOC
dc.relation.journalAnnual International Conference of the IEEE Engineering in Medicine and Biology Society
dc.rightsAcceso Cerradoes_ES
dc.titleTranscranial focal electrical stimulation reduces seizure activity and hippocampal glutamate release during status epilepticuses_ES
dc.typeArtículoes_ES

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