Toll-like receptor (TLR) 1, 2, and 6 gene polymorphisms support evidence of innate immune factors in Schizophrenia

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dc.contributor.affiliationPosgrado en Biología Experimental, Universidad Autónoma Metropolitana-Iztapalapa, México City, México
dc.contributor.emailbcamarenam@gmail.com (Beatriz Camarena)
dc.creatorSotelo-Ramírez, Carlo E.es_ES
dc.creatorCamarena, Beatrizes_ES
dc.creatorSanabrais-Jiménez, Marco Antonioes_ES
dc.creatorZaragoza-Hoyos, Julio Urieles_ES
dc.creatorOrdoñez-Martínez, Brunoes_ES
dc.creatorEscamilla-Orozco, Raul I.es_ES
dc.creatorGómez-González, Beatrizes_ES
dc.date2023
dc.date.accessioned2025-04-25T18:40:36Z
dc.date.accessioned2026-03-27T15:31:51Z
dc.date.available2025-04-25T18:40:36Z
dc.date.issued2023
dc.date.published2023
dc.descriptionIntroduction: Schizophrenia is a complex psychiatric disorder with an important genetic contribution. Immunological abnormalities have been reported in schizophrenia. Toll-like receptor (TLR) genes play an important role in the activation of the innate immune response, which may help to explain the presence of inflammation in people with this disorder. The aim of this study was to analyze the association of TLR1, TLR2, and TLR6 gene polymorphisms in the etiology of schizophrenia. Methods: We included 582 patients with schizophrenia and 525 healthy controls. Genetic analysis was performed using allelic discrimination with TaqMan probes. Results: We observed significant differences between patients and controls in the genotype and allele frequencies of TLR1/rs4833093 (χ2 = 17.3, p = 0.0002; χ2 = 15.9, p = 0.0001, respectively) and TLR2/rs5743709 (χ2 = 29.5, p = 0.00001; χ2 = 7.785, p = 0.0053, respectively), and in the allele frequencies of TLR6/rs3775073 (χ2 = 31.1, p = 0.00001). Finally, we found an interaction between the TLR1/rs4833093 and TLR2/rs5743709 genes, which increased the risk of developing schizophrenia (OR = 2.29, 95% CI [1.75, 3.01]). Discussion: Our findings add to the evidence suggesting that the activation of innate immune response might play an important role in the development of schizophrenia.es_ES
dc.formatPDFes_ES
dc.identifierJC16IC23es_ES
dc.identifier.doi10.2147/NDT.S420952
dc.identifier.eissn1178-2021
dc.identifier.issn1176-6328
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.placeNueva Zelanda
dc.identifier.urihttps://doi.org/10.2147/NDT.S420952
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/8324
dc.language.isoenges_ES
dc.publisherDove Medical Presses_ES
dc.relation19:2353-2361
dc.relation.jnabreviadoNEUROPSYCHIATR DIS TREAT
dc.relation.journalNeuropsychiatric Disease and Treatment
dc.rightsAcceso Cerradoes_ES
dc.subject.kwTLR1
dc.subject.kwTLR2
dc.subject.kwTLR6
dc.subject.kwGene–gene interaction
dc.subject.kwSchizophrenia
dc.subject.kwImmune response
dc.titleToll-like receptor (TLR) 1, 2, and 6 gene polymorphisms support evidence of innate immune factors in Schizophreniaes_ES
dc.typeArtículoes_ES

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