Proteomics and fibromyalgia: a perspective on the study of the inflammatory response in fibromyalgia

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dc.contributor.affiliationLaboratorio de Psicoinmunología, Instituto Nacional de Psiquiatría Ramón de la Fuente, México
dc.contributor.emaillkuriaki@imp.edu.mx
dc.creatorMaldonado-García, José Luises_ES
dc.creatorVega-Ramírez, María Teresaes_ES
dc.creatorPérez-Sánchez, Gilbertoes_ES
dc.creatorBecerril-Villanueva, Enriquees_ES
dc.creatorAlvarez Herrera, Samanthaes_ES
dc.creatorMendieta, Daneliaes_ES
dc.creatorMoreno-Lafont, Marthaes_ES
dc.creatorPavón, Lenines_ES
dc.creator.identificadorhttp://orcid.org/0000-0003-2694-1290 (Maldonado-García, José Luis)
dc.creator.identificadorhttp://orcid.org/0000-0003-2450-4927 (Vega-Ramírez, María Teresa)
dc.creator.identificador(http://orcid.org/0000-0003-3878-0631) Pérez-Sánchez, Gilberto
dc.creator.identificadorhttp://orcid.org/0000-0001-7210-9775 (Becerril-Villanueva, Enrique)
dc.creator.identificador http://orcid.org/0000-0001-9747-885X (Alvarez Herrera, Samantha)
dc.creator.identificadorhttp://orcid.org/0000-0003-2896-5819 (Moreno-Lafont, Martha)
dc.creator.identificadorhttp://orcid.org/0000-0002-6067-6868 (Pavón, Lenin)
dc.date2021
dc.date.accessioned2024-05-29T20:33:21Z
dc.date.accessioned2026-03-27T15:30:08Z
dc.date.available2024-05-29T20:33:21Z
dc.date.issued2021
dc.date.published2021
dc.descriptionFibromyalgia (FM) is a chronic, non-degenerative disease characterized by widespread and sustained pain, sleep disturbances, physical exhaustion, and cognitive difficulties. The FM pathophysiology has not been completely clarified, and several theories have been postulated, among which is the dysregulation of the inflammatory response as a mediator of the painful phenomenon. In addition, it has been reported that FM patients present a rise of IL-6 and IL-8 serum levels; this fact has clinical relevance since these inflammatory molecules induce symptoms such as pain, fatigue, hyperalgesia, and allodynia. Additionally, some studies have been carried out on the participation of leukocytes in the physiopathology of fibromyalgia; The evidence suggests that mast cells are the most relevant leukocytes in the pathophysiology of FM since they promote the release of pro-inflammatory cytokines in response to stimuli such as substance P or corticotropin-releasing hormone, which were elevated in patients. The number of FM patients is increasing year after year around the world. For this reason, it is essential to study the proteins involved in the inflammatory response in fibromyalgia. Proteomic analysis techniques such as tandem mass tag (TMT) with isobaric labeling offer a hope to find biological markers that allow the study simultaneously the participation of multiple inflammatory proteins in FM patients, allowing the identification of biomarkers. Thus, the use of isobaric tagging will allow shortly to expand the knowledge of pathophysiology in fibromyalgia, helping to identify biomarkers to improve the diagnosis of the FM disease and increase the quality of life of patients and their families.es_ES
dc.formatPDFes_ES
dc.identifierJC08NC21es_ES
dc.identifier.doi10.18103/mra.v9i8.2518
dc.identifier.eissn2375-1924
dc.identifier.issn2375-1916
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.placeEstados Unidos
dc.identifier.urihttps://doi.org/10.18103/mra.v9i8.2518
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/7980
dc.language.isoenges_ES
dc.publisherKnowledge Enterprises Incorporatedes_ES
dc.relation9(8):1-16
dc.relation.jnabreviadoMED RES ARCH
dc.relation.journalMedical Research Archives
dc.rightsAcceso Cerradoes_ES
dc.subject.kwFibromyalgia
dc.subject.kwLeucocytes
dc.subject.kwCytokines
dc.subject.kwProteomics
dc.subject.kwTandem mass tag
dc.subject.kwIsobaric label
dc.titleProteomics and fibromyalgia: a perspective on the study of the inflammatory response in fibromyalgiaes_ES
dc.typeArtículoes_ES

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