Mirtazapine decreased cocaine-induced c-fos expression and dopamine release in rats
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Date
2024
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Publisher
Frontiers Research Foundation
Abstract
Description
Chronic cocaine exposure induces an increase in dopamine release and an increase in the expression of the Fos protein in the rat striatum. It has been suggested that both are necessary for the expression of cocaine-induced alterations in behavior and neural circuitry. Mirtazapine dosing attenuated the cocaine-induced psychomotor and reinforcer effects.