Depressant effects of Clinopodium mexicanum Benth. Govaerts (Lamiaceae) on the central nervous system

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dc.contributor.affiliationLaboratorio de Fitofarmacología, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calzada México-Xochimilco 101, Col. San Lorenzo Huipulco, Delegación Tlalpan, Mexico City 14370, Mexico.es_ES
dc.contributor.emailoscar.martinezvazquez@gmail.com, marvaz@servidor.unam.mxes_ES
dc.creatorEstrada-Reyes, R.
dc.creatorMartínez-Vázquez, M.
dc.creatorGallegos-Solís, A.
dc.creatorHeinze, G.
dc.creatorMoreno, J.
dc.creator.identificador"EARR640516MMCSYS04">Estrada Reyes, Rosaes_ES
dc.date.accessioned2017-06-30T01:38:38Z
dc.date.accessioned2026-03-27T14:47:04Z
dc.date.available2017-06-30T01:38:38Z
dc.date.issued2010es_ES
dc.date.published2010es_ES
dc.description.abstractotrodiomaETHNOPHARMACOLOGICAL RELEVANCE: The decoction of leaves of Clinopodium mexicanum Benth. Goaverts (Lamiaceae), commonly known as "Toronjil de Monte", is used in the Mexican traditional medicine to induce sleep, as well as sedative and analgesic remedy. AIM OF THE STUDY: To evaluate the putative depressant effects of an aqueous extract of the medicinal plant Clinopodium mexicanum on the central nervous system (CNS). MATERIALS AND METHODS: The effects of the extract (AECM) on mice were tested in several animal paradigms, including sodium pentobarbital-induced sleep, open field tests, and hole-board tests. The effects of AECM on pentylenetetrazole- and picrotoxin-induced convulsions in mice and on the antithermonociceptive response in the hot-plate paradigm were also tested. Additionally, the active extract (AECM) was analyzed with HPLC-ESI-MS techniques. RESULTS: Mice acutely treated with AECM at 100, 200, 500 and 1000mg/kg doses prolonged the sleeping time induced by sodium pentobarbital (42mg/kg). This extract, at 100 and 200mg/kg doses, showed a sedative effect in the hole-board paradigm and decreased spontaneous activity in mice. AECM at 10, 100 and 200mg/kg prolonged the onset of seizures induced by pentylenetetrazole (90mg/kg) and antagonized tonic convulsions induced by picrotoxin (10mg/kg). Additionally, AECM inhibited the response to a thermonociceptive stimulus. The intraperitoneal AECM treatment produced mortality with an LD(50)=2154mg/kg. Chemical analysis showed that the flavanone glycosides neoponcirin, poncirin, and isonaringenin are the main compounds of the active extract. CONCLUSIONS: This study demonstrates that an acutely administered single dose of an aqueous extract of Clinopodium mexicanum can exert depressant effects on the CNS. These findings are in agreement with the traditional use of Clinopodium mexicanum to induce sleep as well as sedative and analgesic remedy. The chemical analysis of AECM revealed the presence of the flavanone glycosides neoponcirin, poncirin, and isonaringines_ES
dc.description.monthJules_ES
dc.identifier1498es_ES
dc.identifier.citationJuan Carlos Bautista Ramírezes_ES
dc.identifier.doi10.1016/j.jep.2010.03.012es_ES
dc.identifier.eissn1872-7573es_ES
dc.identifier.issn0378-8741es_ES
dc.identifier.numero1es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.paginacion1-8es_ES
dc.identifier.placeIrlandaes_ES
dc.identifier.urihttps://doi.org/10.1016/j.jep.2010.03.012es_ES
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/6179
dc.identifier.volumen130es_ES
dc.language.isoenges_ES
dc.relation130 (1) 1-8 p.es_ES
dc.relationversión del editores_ES
dc.relation.jnabreviadoJ ETHNOPHARMACOLes_ES
dc.relation.journalJournal of Ethnopharmacologyes_ES
dc.rightsacceso cerradoes_ES
dc.subject.koAnimalses_ES
dc.subject.koBehavior, Animales_ES
dc.subject.kodrug effectses_ES
dc.subject.koCentral Nervous Systemes_ES
dc.subject.kodrug effectses_ES
dc.subject.koChromatography, High Pressure Liquides_ES
dc.subject.koDose-Response Relationship, Druges_ES
dc.subject.koLamiaceaees_ES
dc.subject.kochemistryes_ES
dc.subject.koLethal Dose 50es_ES
dc.subject.koMalees_ES
dc.subject.koMicees_ES
dc.subject.koPlant Extractses_ES
dc.subject.kopharmacologyes_ES
dc.subject.koSleepes_ES
dc.subject.kodrug effectses_ES
dc.subject.koSpectrometry, Mass, Electrospray Ionizationes_ES
dc.subject.koPlant Extractses_ES
dc.titleDepressant effects of Clinopodium mexicanum Benth. Govaerts (Lamiaceae) on the central nervous systemes_ES
dc.typearticlees_ES

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