Immunoendocrine peripheral effects induced by atypical antipsychotics

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dc.contributor.affiliationLaboratorio de Psicoinmunología, Dirección de Investigaciones en Neurociencias del Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Ciudad de México, Mexico
dc.contributor.emaillkuriaki@imp.edu.mx (Lenin Pavón)
dc.creatorAlvarez-Herrera, Samanthaes_ES
dc.creatorEscamilla, Raúles_ES
dc.creatorMedina-Contreras, Oscares_ES
dc.creatorSaracco, Ricardoes_ES
dc.creatorFlores,Yvonnees_ES
dc.creatorHurtado-Alvarado, Gabrielaes_ES
dc.creatorMaldonado-García, José Luises_ES
dc.creatorBecerril-Villanueva, Enriquees_ES
dc.creatorPérez-Sánchez, Gilbertoes_ES
dc.creatorPavón, Lenines_ES
dc.creator.identificadorhttps://orcid.org/0000-0001-9747-885X (Alvarez-Herrera, Samantha)
dc.creator.identificadorhttps://orcid.org/0000-0002-6772-9731 (Escamilla, Raúl)
dc.creator.identificadorhttps://orcid.org/0000-0002-4432-7780 (Medina-Contreras, Oscar)
dc.creator.identificadorhttps://orcid.org/0000-0002-0004-1318 (Saracco, Ricardo)
dc.creator.identificadorhttps://orcid.org/0000-0002-4508-8734 (Flores,Yvonne)
dc.creator.identificadorhttps://orcid.org/0000-0002-6137-663X (Hurtado-Alvarado, Gabriela)
dc.creator.identificadorhttps://orcid.org/0000-0003-2694-1290 (Maldonado-García, José Luis)
dc.creator.identificadorhttps://orcid.org/0000-0001-7210-9775 (Becerril-Villanueva, Enrique)
dc.creator.identificadorhttps://orcid.org/0000-0003-3878-0631 (Pérez-Sánchez, Gilberto)
dc.creator.identificadorhttps://orcid.org/0000-0002-6067-6868 (Pavón, Lenin)
dc.date2020
dc.date.accessioned2023-11-15T17:19:06Z
dc.date.accessioned2026-03-27T15:27:12Z
dc.date.available2023-11-15T17:19:06Z
dc.date.issued2020
dc.date.published2020
dc.descriptionAtypical antipsychotics (AAP) or second-generation antipsychotics are the clinical option for schizophrenia treatment during acute psychoses, but they are also indicated for maintenance during lifetime, even though they are being used for other psychiatric conditions in clinical practice such as affective disorders and autism spectrum disorder, among others. These drugs are differentiated from typical antipsychotics based on their clinical profile and are a better choice because they cause fewer side effects regarding extrapyramidal symptoms (EPS). Even though they provide clear therapeutic benefits, AAP induce peripheral effects that trigger phenotypic, functional, and systemic changes outside the Central Nervous System (CNS). Metabolic disease is frequently associated with AAP and significantly impacts the patient's quality of life. However, other peripheral changes of clinical relevance are present during AAP treatment, such as alterations in the immune and endocrine systems as well as the intestinal microbiome. These less studied alterations also have a significant impact in the patient's health status. This manuscript aims to revise the peripheral immunological, endocrine, and intestinal microbiome changes induced by AAP consumption recommended in the clinical guidelines for schizophrenia and other psychiatric disorders.es_ES
dc.formatPDFes_ES
dc.identifierJC03SIC2020es_ES
dc.identifier.doi10.3389/fendo.2020.00195
dc.identifier.eissn1664-2392
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.placeSuiza
dc.identifier.urihttps://doi.org/10.3389/fendo.2020.00195
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/7827
dc.language.isoenges_ES
dc.publisherFrontiers Research Foundationes_ES
dc.relation11: 195
dc.relation.jnabreviadoFRONT ENDOCRINOL
dc.relation.journalFrontiers in Endocrinology
dc.rightsAcceso Cerradoes_ES
dc.subject.kwAtypical antipsychotics (AAP)
dc.subject.kwPeripheral effects
dc.subject.kwInflammatory response
dc.subject.kwEndocrine response
dc.subject.kwMicrobiome
dc.titleImmunoendocrine peripheral effects induced by atypical antipsychoticses_ES
dc.typeArtículoes_ES

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