Cardiovascular effects of different schedules of nicotine administration on spinal rats: influence of pentobarbital

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dc.contributor.affiliationSección de Terapéutica Experimental, Departamento de Farmacología, CINVESTAV, IPN, Mexico, D.F.es_ES
dc.creatorCruz, Silvia L.
dc.creatorFernández-Guasti, Alonso
dc.creator.identificador"FEGA571030HDFRSL07">Fernández Guasti, José Alonsoes_ES
dc.date.accessioned2017-06-29T04:17:39Z
dc.date.accessioned2026-03-27T14:35:12Z
dc.date.available2017-06-29T04:17:39Z
dc.date.issued1994es_ES
dc.date.published1994es_ES
dc.description.abstractotrodiomaThis work examined the cardiovascular effects of different schedules of i.v. nicotine administration with respect to doses and timing in non-anesthetized and pentobarbital-treated spinal rats. For this purpose, complete nicotine dose-response curves were made for mean arterial pressure and heart rate. In non-anesthetized spinal rats, tachyphylaxis was not found for the pressor effects; moreover, consecutive doses, given at short intervals, produced additive actions. Furthermore, nicotine produced a biphasic heart rate response: an initial and brief bradycardia followed by a longer lasting tachycardia. In pentobarbital-treated rats, the sensitivity of the cardiovascular system to nicotine was decreased; in these rats, consecutive nicotine doses did show tachyphylaxis for the pressor and tachycardiac responses. The present series of experiments, using different schedules of administration for single and consecutive nicotine doses, demonstrated opposite tachyphylactic effects in non-anesthetized and in pentobarbital-treated spinal ratses_ES
dc.description.monthJunes_ES
dc.identifier186es_ES
dc.identifier.citationJuan Carlos Bautista Ramírezes_ES
dc.identifier.doi10.1016/0014-2999(94)90055-8es_ES
dc.identifier.eissn1879-0712es_ES
dc.identifier.issn0014-2999es_ES
dc.identifier.numero1-2es_ES
dc.identifier.organizacionInstituto Mexicano de Psiquiatríaes_ES
dc.identifier.paginacion39-45es_ES
dc.identifier.placePaíses Bajoses_ES
dc.identifier.urihttp://dx.doi.org/10.1016/0014-2999(94)90055-8es_ES
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/4880
dc.identifier.volumen258es_ES
dc.language.isoenges_ES
dc.relation258 (1-2) 39-45 p.es_ES
dc.relationversión del editores_ES
dc.relation.jnabreviadoEUR J PHARMACOLes_ES
dc.relation.journalEuropean Journal of Pharmacologyes_ES
dc.rightsacceso cerradoes_ES
dc.subject.koAnimalses_ES
dc.subject.koBlood Pressure-Drug effectses_ES
dc.subject.koBradycardia-Chemically inducedes_ES
dc.subject.koDecerebrate Statees_ES
dc.subject.koDose-Response Relationship, Druges_ES
dc.subject.koDrug Administration Schedulees_ES
dc.subject.koDrug Interactionses_ES
dc.subject.koHeart Rate-Drug effectses_ES
dc.subject.koInjections, Intravenouses_ES
dc.subject.koMalees_ES
dc.subject.koNicotine-Administration & dosagees_ES
dc.subject.koNicotine-Toxicityes_ES
dc.subject.koPentobarbital-Administration & dosagees_ES
dc.subject.koPentobarbital-Pharmacologyes_ES
dc.subject.koRatses_ES
dc.subject.koRats, Wistares_ES
dc.subject.koTachycardia-Chemically inducedes_ES
dc.subject.koTachyphylaxises_ES
dc.subject.koNicotinees_ES
dc.subject.koPentobarbitales_ES
dc.titleCardiovascular effects of different schedules of nicotine administration on spinal rats: influence of pentobarbitales_ES
dc.typearticlees_ES

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