Naloxone facilitates sensory precipitation of focal and generalized seizures: evoked potentials and power spectral analysis in the cat

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dc.contributor.affiliationInstituto Mexicano de Psiquiatríaes_ES
dc.creatorFernández-Guardiola, Augusto
dc.creatorPellicer, Francisco
dc.creatorRocha, Luisa
dc.creatorGutiérrez, Rafael
dc.creator.identificador"FEGA210324HNERRG05">Fernández Guardiola, Augustoes_ES
dc.creator.identificador"http://orcid.org/0000-0002-6566-3900">Gutiérrez, Rafaeles_ES
dc.date.accessioned2017-06-29T04:00:45Z
dc.date.accessioned2026-03-27T14:33:24Z
dc.date.available2017-06-29T04:00:45Z
dc.date.issued1988es_ES
dc.date.published1988es_ES
dc.description.abstractotrodiomaTo analyze the role of endogenous opioids on epileptogenesis the effect of repeated doses of naloxone alone (NA) (2, 4, and 8 mg/kg every 15 min) or along with intermittent photic stimulation (NPS) (1, 3, and 10 Hz) was tested on acute “Encephale isolé” cats. The electrical activity recordings of sensorimotor cortex (SMC), visual cortex, and right and left amygdalae revealed progressive changes as naloxone was administered: (A) slow spindle activity (4–6 Hz) in SMC, (B) 12 Hz rhythmic activity in both amygdalae, (C) generalized paroxysms, and (D) spontaneous tonic-clonic electrographic seizures. These changes occurred in both experimental groups (NA, NPS), and their onset was dose-related. Photic stimulation precipitated these phenomena. The amplitude of the visual evoked potential components (N1-P1, P1-N2, N2-P2) and power spectral analysis of spontaneous and evoked activity underwent progressive changes. Our results confirm a facilitatory effect of naloxone on epileptogenesis and suggest a possible role of endogenous opioids in this process and on sensory pathways' excitabilityes_ES
dc.description.monthAgoes_ES
dc.identifier2840es_ES
dc.identifier.citationElizabeth Cuesta Hernándezes_ES
dc.identifier.eissn1090-2430es_ES
dc.identifier.issn0014-4886es_ES
dc.identifier.numero2es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.paginacion159-175es_ES
dc.identifier.placeEstados Unidoses_ES
dc.identifier.urihttps://doi.org/10.1016/0014-4886(88)90001-5es_ES
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/4689
dc.identifier.volumen101es_ES
dc.language.isoenges_ES
dc.publisherOrlando Fl : Academic Presses_ES
dc.relation101 (2) 159-175 p.es_ES
dc.relationversión del editores_ES
dc.relation.jnabreviadoEXP NEUROLes_ES
dc.relation.journalExperimental Neurologyes_ES
dc.rightsacceso cerradoes_ES
dc.titleNaloxone facilitates sensory precipitation of focal and generalized seizures: evoked potentials and power spectral analysis in the cates_ES
dc.typeartículoes_ES

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