Relationship of cognitive functioning with progenitor cells of the olfactory epithelium in patients with depression after eight weeks of fluoxetine treatment

Simple item page
dc.contributor.affiliationProgram in Medical Sciences, Universidad Nacional Autónoma de México (National Autonomous University of Mexico)
dc.contributor.emailflores_ramos@hotmail.com, monica.flores@imp.edu.mx (M. Flores-Ramos)
dc.creatorAmado Lerma, Javieres_ES
dc.creatorFlores-Ramos, Mónicaes_ES
dc.creatorTirado Durán, Elsaes_ES
dc.creatorEnciso Araujo, José Migueles_ES
dc.creatorBurrola Suárez, Martín Armandoes_ES
dc.creatorGuiza Zayas, Rodrigoes_ES
dc.creatorRomero-Luevano, Perla Vanessaes_ES
dc.creatorOrtiz-López, Leonardoes_ES
dc.creatorRamírez-Rodríguez, Gerardo Bernabées_ES
dc.date2023
dc.date.accessioned2025-05-21T19:57:38Z
dc.date.accessioned2026-03-27T15:32:14Z
dc.date.available2025-05-21T19:57:38Z
dc.date.issued2023
dc.date.published2023
dc.descriptionDepression is related to cognitive dysfunction, which could be mediated by alterations in neurogenesis. Research suggests that pharmacological treatment induces cognitive changes by generating neurogenesis-promoting factors at least in animal models of depression. Interestingly, several studies suggest that olfactory alterations occurred in depression. Those alterations may be linked to the neurogenic process occurring in the olfactory epithelium. Thus, the objective of this study was to evaluate the relationship between progenitor cells of the olfactory epithelium (OPC) and cognitive functioning in patients with depression before and after eight weeks of fluoxetine treatment. The initial and final measurements revealed a significant relationship of OPC with the Rey–Osterrieth Complex Figure Test, but a significant relationship was only observed between brain-derived neurotrophic factor (BDNF) quantified in the conditioned medium of OPC and the Digit Ordering Test in the final measurements. We propose a relationship between the OPC and visuospatial capacity, working memory and information organization. However, changes in the expression of neurogenesis marker proteins in the OPC as a biological reading of the benefits of antidepressant treatment and its relationship with cognitive functions deserve to be studied in the future.es_ES
dc.formatPDFes_ES
dc.identifierJC08SC23es_ES
dc.identifier.doi10.1016/j.psycom.2022.100095
dc.identifier.eissn2772-5987
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.placePaíses Bajos
dc.identifier.urihttps://doi.org/10.1016/j.psycom.2022.100095
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/8367
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relation3(1):100095
dc.relation.jnabreviadoPSYCHIATRY RES COMMUN
dc.relation.journalPsychiatry Research Communications
dc.rightsAcceso Cerradoes_ES
dc.subject.kwDepressive disorder
dc.subject.kwAdult neurogenesis
dc.subject.kwBDNF
dc.subject.kwMemory
dc.subject.kwOlfactory epithelium
dc.subject.kwMemory and learning tests
dc.subject.kwRey-osterrieth complex figure
dc.titleRelationship of cognitive functioning with progenitor cells of the olfactory epithelium in patients with depression after eight weeks of fluoxetine treatmentes_ES
dc.typeArtículoes_ES

Files

License bundle

Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Plain Text
Description:
Download

Collections

Artículos de revista