Age of onset and cumulative risk of mental disorders: a cross-national analysis of population surveys from 29 countries

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dc.contributor.affiliationQueensland Centre for Mental Health Research, Brisbane, QLD, Australia; Queensland Brain Institute, The University of Queensland, Brisbane, QLD, Australia; National Centre for Register-based Research, Aarhus University, Aarhus, Denmark
dc.contributor.emailj.mcgrath@uq.edu.au (McGrath, John J.)
dc.creatorMcGrath, John J.es_ES
dc.creatorAl-Hamzawi, Alies_ES
dc.creatorAlonso, Jordies_ES
dc.creatorAltwaijri, Yasmines_ES
dc.creatorAndrade, Laura H.es_ES
dc.creatorBromet, Evelyn J.es_ES
dc.creatorBruffaerts, Ronnyes_ES
dc.creatorCaldas de Almeida, José Migueles_ES
dc.creatorChardoul, Stephaniees_ES
dc.creatorChiu, Wai Tates_ES
dc.creatorDegenhardt, Louisaes_ES
dc.creatorDemler, Olga V.es_ES
dc.creatorFerry, Finolaes_ES
dc.creatorGureje, Oyees_ES
dc.creatorHaro, Josep Mariaes_ES
dc.creatorKaram, Elie G.es_ES
dc.creatorKaram, Georgeses_ES
dc.creatorKhaled, Salma M.es_ES
dc.creatorKovess-Masfety, Vivianees_ES
dc.creatorMagno, Martaes_ES
dc.creatorMedina-Mora, Maria Elenaes_ES
dc.creatorMoskalewicz, Jacekes_ES
dc.creatorNavarro-Mateu, Fernandoes_ES
dc.creatorNishi, Daisukees_ES
dc.creatorPlana-Ripoll, Olegueres_ES
dc.creatorPosada-Villa, Josées_ES
dc.creatorRapsey, Charlenees_ES
dc.creatorSampson, Nancy A.es_ES
dc.creatorStagnaro, Juan Carloses_ES
dc.creatorStein, Dan J.es_ES
dc.creatorHave, Margreet tenes_ES
dc.creatorTorres, Yolandaes_ES
dc.creatorVladescu, Cristianes_ES
dc.creatorWoodruff, Peter W.es_ES
dc.creatorZarkov, Zaharies_ES
dc.creatorKessler, Ronald C.es_ES
dc.creatorWHO World Mental Health Survey Collaboratorses_ES
dc.creatorAguilar-Gaxiola, Sergio
dc.creatorAl-Hamzawi, Ali
dc.creatorAlonso, Jordi
dc.creatorAltwaijri, Yasmin A.
dc.creatorAndrade, Laura Helena
dc.creatorAtwoli, Lukoye
dc.creatorBenjet, Corina
dc.creatorBromet, Evelyn J.
dc.creatorBruffaerts, Ronny
dc.creatorBunting, Brendan
dc.creatorCaldas-de-Almeida, José Miguel
dc.creatorCardoso, Graça
dc.creatorChardoul, Stephanie
dc.creatorCía, Alfredo H.
dc.creatorDegenhardt, Louisa
dc.creatorGirolamo, Giovanni De
dc.creatorGureje, Oye
dc.creatorHaro, Josep Maria
dc.creatorHarris, Meredith G.
dc.creatorHinkov, Hristo
dc.creatorHu, Chi-Yi
dc.creatorJonge, Peter De
dc.creatorKaram, Aimee N.
dc.creatorKaram, Elie G.
dc.creatorKaram, Georges
dc.creatorKazdin, Alan E.
dc.creatorKawakami, Norito
dc.creatorKessler, Ronald C.
dc.creatorKiejna, Andrzej
dc.creatorKovess-Masfety, Viviane
dc.creatorMcGrath, John J.
dc.creatorMoskalewicz, Jacek
dc.creatorNavarro-Mateu, Fernando
dc.creatorNishi, Daisuke
dc.creatorPiazza, Marina
dc.creatorPosada-Villa, José
dc.creatorScott, Kate M.
dc.creatorStagnaro, Juan Carlos
dc.creatorStein, Dan J.
dc.creatorHave, Margreet Ten
dc.creatorTorres, Yolanda
dc.creatorViana, Maria Carmen
dc.creatorVigo, Daniel V.
dc.creatorVladescu, Cristian
dc.creatorWilliams, David R.
dc.creatorWoodruff, Peter
dc.creatorWojtyniak, Bogdan
dc.creatorXavier, Miguel
dc.creatorZaslavsky, Alan M.
dc.date2023
dc.date.accessioned2025-05-28T18:47:16Z
dc.date.accessioned2026-03-27T15:32:17Z
dc.date.available2025-05-28T18:47:16Z
dc.date.issued2023
dc.date.published2023
dc.descriptionBackground: Information on the frequency and timing of mental disorder onsets across the lifespan is of fundamental importance for public health planning. Broad, cross-national estimates of this information from coordinated general population surveys were last updated in 2007. We aimed to provide updated and improved estimates of age-of-onset distributions, lifetime prevalence, and morbid risk. Methods: In this cross-national analysis, we analysed data from respondents aged 18 years or older to the World Mental Health surveys, a coordinated series of cross-sectional, face-to-face community epidemiological surveys administered between 2001 and 2022. In the surveys, the WHO Composite International Diagnostic Interview, a fully structured psychiatric diagnostic interview, was used to assess age of onset, lifetime prevalence, and morbid risk of 13 DSM-IV mental disorders until age 75 years across surveys by sex. We did not assess ethnicity. The surveys were geographically clustered and weighted to adjust for selection probability, and standard errors of incidence rates and cumulative incidence curves were calculated using the jackknife repeated replications simulation method, taking weighting and geographical clustering of data into account. Findings: We included 156 331 respondents from 32 surveys in 29 countries, including 12 low-income and middle-income countries and 17 high-income countries, and including 85 308 (54·5%) female respondents and 71 023 (45·4%) male respondents. The lifetime prevalence of any mental disorder was 28·6% (95% CI 27·9-29·2) for male respondents and 29·8% (29·2-30·3) for female respondents. Morbid risk of any mental disorder by age 75 years was 46·4% (44·9-47·8) for male respondents and 53·1% (51·9-54·3) for female respondents. Conditional probabilities of first onset peaked at approximately age 15 years, with a median age of onset of 19 years (IQR 14-32) for male respondents and 20 years (12-36) for female respondents. The two most prevalent disorders were alcohol use disorder and major depressive disorder for male respondents and major depressive disorder and specific phobia for female respondents. Interpretation: By age 75 years, approximately half the population can expect to develop one or more of the 13 mental disorders considered in this Article. These disorders typically first emerge in childhood, adolescence, or young adulthood. Services should have the capacity to detect and treat common mental disorders promptly and to optimise care that suits people at these crucial parts of the life course. Funding: None.es_ES
dc.formatPDFes_ES
dc.identifierJC03DIEP23es_ES
dc.identifier.doi10.1016/S2215-0366
dc.identifier.eissn2215-0374
dc.identifier.issn2215-0366
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.placeInglaterra
dc.identifier.urihttps://doi.org/10.1016/S2215-0366(23)00193-1
dc.identifier.urihttps://pmc.ncbi.nlm.nih.gov/articles/PMC10529120/
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/8373
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relation10(9):668-681
dc.relation.jnabreviadoLANCET PSYCHIATRY
dc.relation.journalLancet Psychiatry
dc.rightsAcceso Cerradoes_ES
dc.titleAge of onset and cumulative risk of mental disorders: a cross-national analysis of population surveys from 29 countrieses_ES
dc.typeArtículoes_ES

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