No association between ApoE and schizophrenia: evidence of systematic review and updated meta-analysis

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dc.contributor.affiliationUniversidad Juárez Autónoma de Tabasco, División Académica Multidisciplinaria de Jalpa de Méndez, Cunduacán, Tabasco, Mexico. Electronic address: thelma.glez.castro@gmail.com
dc.contributor.emailthelma.glez.castro@gmail.com (T.B. González-Castro), alfonso_tovillaz@yahoo.com.mx (C.A. Tovilla-Zárate), yazmin.hdez.diaz@gmail.com, (Y. Hernández-Díaz), fresan@imp.edu.mx (A. Fresán), iselajua22@yahoo.com.mx, (I.E. Juárez-Rojop), jblecastillo@hotmail.com (J.L. Ble-Castillo), dralilialonar@yahoo.com.mx (L. López-Narváez), adgenis@inmegen.gob.mx (A. Genis), thelma.glezcastro@yahoo.com.mx (M.M. Hernández-Alvarado)
dc.creatorGonzález-Castro, Thelma Beatrizes_ES
dc.creatorTovilla-Zárate, Carlos Alfonsoes_ES
dc.creatorHernández-Díaz, Yazmínes_ES
dc.creatorFresán, Anaes_ES
dc.creatorJuárez-Rojop, Isela E.es_ES
dc.creatorBle-Castillo, Jorge L.es_ES
dc.creatorLópez-Narváez, Liliaes_ES
dc.creatorGenis, Almaes_ES
dc.creatorHernández-Alvarado, Mervyn Manueles_ES
dc.date2015
dc.date.accessioned2025-10-22T19:04:04Z
dc.date.accessioned2026-03-27T15:33:22Z
dc.date.available2025-10-22T19:04:04Z
dc.date.issued2015
dc.date.published2015
dc.descriptionIntroduction: Schizophrenia affects between 0.3% and 2% of the worldwide population. A genetic contribution has been postulated in the development of this disorder. Genes such as ApoE have been implicated in the neurodevelopment associated with schizophrenia in case-control and meta-analysis studies, but the results remain inconclusive. Due to this, the aim of the present study was to explore the association between ApoE and schizophrenia through a meta-analysis. Material and methods: We collected all relevant studies by searching PubMed and EBSCO databases. The pooled odds ratios with 95% confidence intervals were calculated to estimate the association. The following models were evaluated: A) ε4 vs ε3, B) ε4 vs ε2, C) ε4 vs ε3+ε2, D) Caucasian population and E) Asian population. Statistical analyses were performed using EPIDAT 3.1 software. Results: The meta-analyses comprised 28 association studies, which included 4703 controls and 3452 subjects with schizophrenia. A significant protective effect was found for allele ε3 in the Asian population (OR=0.73, 95% CI=0.54-0.98). No significant associations were observed in the other models and populations analyzed. Conclusions: Our meta-analysis suggests a protective association between ApoE allele ε3 and schizophrenia in the Asian population.es_ES
dc.formatPDFes_ES
dc.identifier.doi10.1016/j.schres.2015.08.031
dc.identifier.eissn1573-2509
dc.identifier.issn0920-9964
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.placePaíses Bajos
dc.identifier.urihttps://doi.org/10.1016/j.schres.2015.08.031
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/8475
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relation169(1-3):355-368
dc.relation.jnabreviadoSCHIZOPHR RES
dc.relation.journalSchizophrenia Research
dc.rightsAcceso Cerradoes_ES
dc.subject.kwApoE gene
dc.subject.kwSystematic review
dc.subject.kwMeta-analysis
dc.subject.kwSchizophrenia
dc.titleNo association between ApoE and schizophrenia: evidence of systematic review and updated meta-analysises_ES
dc.typeArtículoes_ES

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