Extrasynapticexocytosisanditsmechanisms:asourceofmoleculesmediatingvolumetransmissioninthenervoussystem

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dc.contributor.affiliationDepartamentodeNeurofisiología,InstitutoNacionaldePsiquiatríaRamóndelaFuenteMuñiz,México,D.F.,Méxicoes_ES
dc.contributor.emailctrueta@imp.edu.mxes_ES
dc.creatorTrueta, Citlali
dc.creatorDe-Miguel, Francisco F.
dc.creator.identificador"TUSC720608MDFRGT06">Trueta, Citlalies_ES
dc.date.accessioned2017-06-29T03:49:31Z
dc.date.accessioned2026-03-27T14:32:58Z
dc.date.available2017-06-29T03:49:31Z
dc.date.issued2012es_ES
dc.date.published2012es_ES
dc.description.abstractotrodiomaWereviewtheevidenceofexocytosisfromextrasynapticsitesinthesoma,dendrites,andaxonalvaricositiesofcentralandperipheralneuronsofvertebratesandinvertebrates,withemphasisonsomaticexocytosis,andhowitcontributestosignalinginthenervoussystem.Thefindingofsecretoryvesiclesinextrasynapticsitesofneurons,thepresenceofsignalingmolecules(namelytransmittersorpeptides)intheextracellularspaceoutsidesynapticclefts,andthemismatchbetweenexocytosissitesandthelocationofreceptorsforthesemoleculesinneuronsandglialcells,havelongsuggestedthatinadditiontosynapticcommunication,transmittersarereleased,andactextrasynaptically.Thecatalogofthesemoleculesincludeslowmolecularweighttransmitterssuchasmonoamines,acetylcholine,glutamate,gama-aminobutiricacid(GABA),adenosine-5-triphosphate(ATP),andalistofpeptidesincludingsubstanceP,brain-derivedneurotrophicfactor(BDNF),andoxytocin.Bycomparingthemechanismsofextrasynapticexocytosisofdifferentsignalingmoleculesbyvariousneurontypesweshowthatitisawidespreadmechanismforcommunicationinthenervoussystemthatusescertaincommonmechanisms,whicharedifferentfromthoseofsynapticexocytosisbutsimilartothoseofexocytosisfromexcitableendocrinecells.Somaticexocytosishasbeenmeasureddirectlyindifferentneurontypes.Itstartsafterhigh-frequencyelectricalactivityorlongexperimentaldepolarizationsandmaycontinueforseveralminutesaftertheendofstimulation.ActivationofL-typecalciumchannels,calciumreleasefromintracellularstoresandvesicletransporttowardstheplasmamembranecoupleexcitationandexocytosisfromsmallclearorlargedensecorevesiclesinreleasesiteslackingpostsynapticcounterparts.Thepresenceofsynapticandextrasynapticexocytosisendowsindividualneuronswithawidevarietyoftime-andspace-dependentcommunicationpossibilities.Extrasynapticexocytosismaybethemajorsourceofsignalingmoleculesproducingvolumetransmissionandbydoingsomaybepartofalongdurationsignalingmodeinthenervoussystem.es_ES
dc.description.monthSepes_ES
dc.identifier2717es_ES
dc.identifier.citationMaría Teresa Cordero Ortizes_ES
dc.identifier.doi10.3389/fphys.2012.00319es_ES
dc.identifier.eissn1664-042Xes_ES
dc.identifier.numero319es_ES
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñizes_ES
dc.identifier.paginacion1-19es_ES
dc.identifier.placeSuizaes_ES
dc.identifier.urihttps://doi.org/10.3389/fphys.2012.00319
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/4566
dc.identifier.volumen3es_ES
dc.language.isoenges_ES
dc.publisherFrontiers Media S.Aes_ES
dc.relation3 (319) 1-19 p.es_ES
dc.relationversión del editores_ES
dc.relation.jnabreviadoFRONT PHYSIOLes_ES
dc.relation.journalFrontiers in Physiologyes_ES
dc.rightsacceso cerradoes_ES
dc.subject.koExocytosises_ES
dc.subject.koExtrasynaptices_ES
dc.subject.koSerotonines_ES
dc.subject.koSomatic exocytosises_ES
dc.subject.koVolume transmissiones_ES
dc.subject.koMmechanisms of extrasynaptic exocytosises_ES
dc.titleExtrasynapticexocytosisanditsmechanisms:asourceofmoleculesmediatingvolumetransmissioninthenervoussystemes_ES
dc.typeartículoes_ES

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