Chenopodium incisum Aerial Parts Extract Induces Anxiolytic-Like Effects in Mice

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dc.contributor.affiliationDepartamento de Sistemas Biológicos, Universidad Autónoma Metropolitana, Unidad Xochimilco, Ciudad de Mexico, Mexico
dc.contributor.emailrestrada@imp.edu.mx (Rosa Estrada-Reyes)
dc.creatorCassani, Juliaes_ES
dc.creatorDorantes-Barrón, Ana Maríaes_ES
dc.creatorMostalac-Buentello, Diegoes_ES
dc.creatorAdán-Ruiz, Aztlanies_ES
dc.creatorGonzález-Hidalgo, Beatrizes_ES
dc.creatorArrieta-Báez, Danieles_ES
dc.creatorEstrada-Reyes, Rosaes_ES
dc.date2020
dc.date.accessioned2023-05-30T16:22:24Z
dc.date.accessioned2026-03-27T15:26:11Z
dc.date.available2023-05-30T16:22:24Z
dc.date.issued2020
dc.date.published2020
dc.descriptionChenopodium incisum Poir., Amaranthaceae, is employed as a remedy to alleviate susto, a culture-bound syndrome. This study evaluated the anxiolytic-like effect of a single oral dose of a hydroethanolic extract of C. incisum and two of its main constituents, pinostrobin and stigmasterol, in the elevated plus maze and hole-board test in mice. The nonspecific effects of the drugs on the ambulatory activity of mice were evaluated in the open field test. The acute toxicity of the extract was determined, and the extract composition was analyzed. The extract at 50, 100, and 200 mg/kg, as well as pinostrobin and stigmasterol (1 to 30 mg/kg), induced anxiolytic-like effects in both the elevated plus maze and in the hole-board tests, significantly increasing the exploratory behaviors. The anxiolytic actions of drugs were not associated with changes in the ambulatory activity of animals. No evidence of toxicity was observed in the animals treated with hydroethanolic extract of C. incisum. The mean lethal dose was higher than 2000 mg/kg. Chenopodium incisum elicited anxiolytic effects in mice. To the best of our knowledge, this is the first report regarding the anxiolytic effect of pinostrobin. Our results suggest that C. incisum is beneficial to patients with mood disorders.es_ES
dc.formatPDFes_ES
dc.identifierJC15NC20es_ES
dc.identifier.doi10.1007/s43450-020-00011-x
dc.identifier.eissn1981-528X
dc.identifier.issn0102-695X
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.placeBrasil
dc.identifier.urihttps://doi.org/10.1007/s43450-020-00011-x
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/7703
dc.language.isoenges_ES
dc.publisherSpringeres_ES
dc.relation30:132-138
dc.relation.jnabreviadoREV BRAS FARMACOGN
dc.relation.journalRevista Brasileira de Farmacognosia
dc.rightsAcceso Cerradoes_ES
dc.subject.kwPinostrobin
dc.subject.kwMood disorders
dc.subject.kwAnxiety
dc.subject.kwFlavonoids
dc.subject.kwStigmasterol
dc.subject.kwBenzodiazepine
dc.subject.kwPinocembrin
dc.subject.kwNervous
dc.titleChenopodium incisum Aerial Parts Extract Induces Anxiolytic-Like Effects in Micees_ES
dc.typeArtículoes_ES

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