TRH in the nucleus accumbens acts downstream to α-MSH to decrease food intake in rats

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dc.contributor.affiliationMolecular Neurophysiology Laboratory, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calz. México-Xochimilco No. 101. San Lorenzo Huipulco, CDMX 14370. Mexico
dc.contributor.emailgortari@imp.edu.mx (P. de Gortari)
dc.creatorAlvarez-Salas, E.es_ES
dc.creatorGama, F.es_ES
dc.creatorMatamoros-Trejo, G.es_ES
dc.creatorAmaya, MI.es_ES
dc.creatorde Gortari, P.es_ES
dc.date2020
dc.date.accessioned2023-06-13T15:25:36Z
dc.date.accessioned2026-03-27T15:26:15Z
dc.date.available2023-06-13T15:25:36Z
dc.date.issued2020
dc.date.published2020
dc.descriptionFeeding-regulatory peptides such as thyrotropin-releasing hormone (TRH), α-melanocyte-stimulating hormone (α-MSH) and their receptors are expressed in brain regions involved in the homeostatic and hedonic control of food intake, such as the hypothalamus and the mesolimbic system, respectively. The nucleus accumbens (NAc) is part of the latter, a brain circuit involved in processing reward stimuli and the appetitive motivation of feeding. When TRH or α-MSH are administered in the NAc, both decrease food intake, through activating their respective receptors, TRH-R1 and MC4R. The actions of α-MSH as a homeostatic feeding-regulator involves the increase of hypothalamic TRH expression, thus, we aimed to identify whether TRH signaling in the NAc was also participating in α-MSH-induced reduction of food intake. α-MSH administration in the NAc of 48 h fasted rats reduced their food intake during the 2-h period of refeeding, increased accumbal TRH mRNA expression and decreased that of MC4R. Such downregulated MC4R mRNA levels implied a compensatory decrease of α-MSH actions in the NAc after the previous pathway stimulation. The co-administration of α-MSH along with an antisense oligonucleotide directed against pro-TRH mRNA in the NAc impaired the α-MSH-induced feeding reduction, supporting that the accumbal TRHergic pathway is downstream of α-MSH actions to inhibit feeding. Our results suggested that TRH in the NAc mediates some effects of α-MSH on inhibition of food intake; this supports the role of TRH not only as a homeostatic regulator but also as modulating the motivational aspects of feeding.es_ES
dc.formatPDFes_ES
dc.identifierJC23NC20es_ES
dc.identifier.doi10.1016/j.neulet.2020.135403
dc.identifier.eissn1872-7972
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.placeIrlanda
dc.identifier.urihttps://doi.org/10.1016/j.neulet.2020.135403
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/7711
dc.language.isoenges_ES
dc.publisherElsevier Scientific Publishers Irelandes_ES
dc.relation739:135403
dc.relation.jnabreviadoNEUROSCI LETT
dc.relation.journalNeuroscience Letters
dc.rightsAcceso Cerradoes_ES
dc.subject.kwα-MSH
dc.subject.kwThyrotropin-Releasing hormone
dc.subject.kwNucleus accumbens
dc.subject.kwFeeding
dc.titleTRH in the nucleus accumbens acts downstream to α-MSH to decrease food intake in ratses_ES
dc.typeArtículoes_ES

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