Age-related changes in the antidepressant-like effect of desipramine and fluoxetine in the rat forced-swim test

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dc.contributor.affiliationDepartment of Neuroscience Research, National Institute of Psychiatry Ramon de la Fuente Muñiz, 101 Mexico-Xochimilco Street, Mexico City 14370, Mexico. Department of Pharmacobiology, Center for Research and Advanced Studies (CINVESTAV), Mexico City, Mexicoes_ES
dc.contributor.emaillucia@imp.edu.mxes_ES
dc.creatorOlivares-Nazario, Maribel
dc.creatorFernández-Guasti, Alonso
dc.creatorMartínez-Mota, Lucía
dc.creator.identificadorFEGA571030HDFRSL07>Fernández Guasti, Alonsoes_ES
dc.creator.identificadorhttp://orcid.org/0000-0002-0014-7884>Martínez Mota, Lucíaes_ES
dc.date.accessioned2017-06-29T03:41:12Z
dc.date.accessioned2026-03-27T14:32:55Z
dc.date.available2017-06-29T03:41:12Z
dc.date.issued2016es_ES
dc.date.published2016es_ES
dc.description.abstractotrodiomaSome reports suggest that older patients are less responsive to antidepressants than young adults, but this idea has not been fully supported. Here, we investigated the role of aging in the behavioral effects of the antidepressants, desipramine (DMI) (5, 10, and 20 mg/kg) and fluoxetine (FLX) (5, 10, and 20 mg/kg) in young adults (3–5 months), middle-aged (MA, 12–15 months), and senescent (SE, 23–25 months) male rats in the forced-swim test. In addition, locomotor activity and motor coordination were assessed as side-effects. DMI and fluoxetine produced an antidepressant-like effect in YA and MA animals, although in the latter group, a shift to the right in the dose–response curve was found for DMI. Importantly, neither drug was effective in SE animals. Motor side-effects were produced mainly by DMI in MA and SE rats. Therefore, a decrease in the antidepressant-like effect is associated strongly with senescence as well as an increased vulnerability to motor side-effects, particularly of tricyclics. This study is significant because SE animals are scarcely studied in pharmacological screening tests, and our findings might be useful for improving antidepressant treatments for the increasing aged populationes_ES
dc.description.monthFebes_ES
dc.identifier2523es_ES
dc.identifier.citationElizabeth Cuesta Hernándezes_ES
dc.identifier.doi10.1097/FBP.0000000000000175es_ES
dc.identifier.eissn1473-5849es_ES
dc.identifier.issn0955-8810es_ES
dc.identifier.numero1es_ES
dc.identifier.paginacion22-28es_ES
dc.identifier.placeInglaterraes_ES
dc.identifier.urihttp://doi.org/10.1097/FBP.0000000000000175es_ES
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/4372
dc.identifier.volumen27es_ES
dc.language.isoenges_ES
dc.relation27(1):22-28es_ES
dc.relationversión del editores_ES
dc.relation.jnabreviadoBEHAV PHARMACOLes_ES
dc.relation.journalBehavioural Pharmacologyes_ES
dc.rightsAcceso Cerradoes_ES
dc.subject.kwAging
dc.subject.kwAntidepressant drugs
dc.subject.kwForced-swim test
dc.subject.kwMiddle age
dc.subject.kwRat
dc.subject.kwSenescence
dc.titleAge-related changes in the antidepressant-like effect of desipramine and fluoxetine in the rat forced-swim testes_ES
dc.typeArtículoes_ES

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