Anxiolytic actions of diazepam, but not of buspirone, are influenced by gender and the endocrine stage

Simple item page
dc.contributor.affiliationSección de Terapéutica Experimental, Departamento de Farmacología y Toxicología, CINVESTAV, Apartado Postal 22026, México 14 000 D.F.; Instituto Mexicano de Psiquiatría, México D.F., Méxicoes_ES
dc.contributor.emailfegu@cenids.ssa.gob.mxes_ES
dc.creatorFernández-Guasti, A.
dc.creatorPicazo, O.
dc.creator.identificador"FEGA571030HDFRSL07">Fernández Guasti, José Alonsoes_ES
dc.date.accessioned2017-06-29T04:20:09Z
dc.date.accessioned2026-03-27T14:35:19Z
dc.date.available2017-06-29T04:20:09Z
dc.date.issued1997es_ES
dc.date.published1997es_ES
dc.description.abstractotrodiomaThe effect of diazepam (1.0 mg:kg, ip) and buspirone (5.0 mg:kg, ip) on the burying behaviour latency (denoting actions on the animals’ reactivity) and on the cumulative burying behaviour (directly reflecting the experimental anxiety levels), were analyzed in male-, intact females, at proestrus and metoestrus, and in neonatally-androgenized-rats. Androgenization was performed by injecting 60 mg:rat of testosterone propionate on day 5 after delivery. Two main groups of neonatally-androgenized rats were established: A group of animals showing permanent oestrus from the vaginal opening (acyclic females) and a group presenting the delayed anovulatory syndrome. Diazepam produced a clear reduction in experimental anxiety in males and neonatally-androgenized-females. Particularly important was the anxiolytic effect of diazepam on acyclic females that was accompanied by a significant increase in burying behaviour latency. Conversely, buspirone induced a clear reduction in burying behaviour, without modifying its latency, in all groups regardless of the gender and the neonatal treatment. Data are discussed on the basis of the androgen participation on the anxiolytic drug effects. A possible age-related benzodiazepine actions in females is suggested.es_ES
dc.description.monthNoves_ES
dc.identifier240es_ES
dc.identifier.citationMaría Guadalupe Camal Ibáñezes_ES
dc.identifier.issn0166-4328es_ES
dc.identifier.numero2es_ES
dc.identifier.organizacionInstituto Mexicano de Psiquiatríaes_ES
dc.identifier.paginacion213-218es_ES
dc.identifier.placeAmsterdam, Holandaes_ES
dc.identifier.urihttps://doi.org/10.1016/S0166-4328(97)00047-8es_ES
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/4934
dc.identifier.volumen88es_ES
dc.language.isoenges_ES
dc.relation88 (2) 213-218 p.es_ES
dc.relationversión del editores_ES
dc.relation.jnabreviadoBEHAV BRAIN RESes_ES
dc.relation.journalBehavioural Brain Researches_ES
dc.rightsacceso cerradoes_ES
dc.subject.koAnxietyes_ES
dc.subject.koBurying behavioures_ES
dc.subject.koDiazepames_ES
dc.subject.koBuspironees_ES
dc.subject.koGender differenceses_ES
dc.subject.koNeonatal androgenizationes_ES
dc.subject.kwAnsiedades_ES
dc.subject.kwDiazepames_ES
dc.subject.kwBuspironaes_ES
dc.subject.kwEnterrar comportamientoes_ES
dc.subject.kwDiferencias de géneroes_ES
dc.subject.kwAndrogenizaciónes_ES
dc.subject.kwNeonatales_ES
dc.titleAnxiolytic actions of diazepam, but not of buspirone, are influenced by gender and the endocrine stagees_ES
dc.typearticlees_ES

Files

Collections

Artículos de revista