Melatonin reverses the depression-associated behaviour and regulates microglia, fractalkine expression and neurogenesis in adult mice exposed to chronic mild stress

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dc.contributor.affiliationLaboratorio de Neuropsicofarmacología, Dirección de Neurociencias, Instituto Nacional de Psiquiatría ‘‘Ramón de la Fuente Muñiz”, Calz. México-Xochimilco 101, 14370 Ciudad de México, México
dc.contributor.emailgbernabe@imp.edu.mx (G. B. Ramírez-Rodríguez)
dc.creatorVega-Rivera, Nelly Maritzaes_ES
dc.creatorOrtiz-López, Leonardoes_ES
dc.creatorGranados-Juárez, Andreaes_ES
dc.creatorEstrada-Camarena, Erika Monserrates_ES
dc.creatorRamírez-Rodríguez, Gerardo Bernabées_ES
dc.date2020
dc.date.accessioned2023-05-25T15:58:45Z
dc.date.accessioned2026-03-27T15:26:09Z
dc.date.available2023-05-25T15:58:45Z
dc.date.issued2020
dc.date.published2020
dc.descriptionDepression may be precipitated by the negative impact of chronic stress, which is considered to play a key role in this neuropsychiatric disorder. Interestingly, depressed patients show decreased levels of melatonin. This hormone acts pro-neurogenic and exhibits anti-depressant effects in rodent models of predictive antidepressant-like effects. However, the benefits of melatonin in reversing the deleterious effects of chronic mild stress on the alterations in behaviour and in the neurogenic niche of the hippocampus in male BALB/c mice are unknown. In this study, we compared the effects of melatonin (2.5 mg/kg) and citalopram (5 mg/kg), an antidepressant drug belonging to the selective serotonin reuptake inhibitors, in male BALB/c mice exposed to chronic mild stress (CMS). We also investigated the potential effects of melatonin and citalopram on microglial cells, hippocampal neurogenesis and peripheral cytokine profiles. Melatonin and citalopram induced similar antidepressant-like activities that occurred with some of the the following findings: (1) reversal of the morphological alterations in microglia; (2) reversal of the decreased immunoreactivity to CX3CL1 and CX3CR1 in the dentate gyrus; (3) positive regulation of cell proliferation, survival and complexity of the dendritic trees of doublecortin-cells; and (4) modifications of peripheral CX3CL1 expression. This outcome is consistent with the hypothesis about the antidepressant-like effect of melatonin and supports its relevance as a modulator of the niche in the dentate gyrus.es_ES
dc.formatPDFes_ES
dc.identifierJC05NC20es_ES
dc.identifier.doi10.1016/j.neuroscience.2020.05.014
dc.identifier.eissn1873-7544
dc.identifier.issn0306-4522
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.placeEstados Unidos
dc.identifier.urihttps://doi.org/10.1016/j.neuroscience.2020.05.014
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/7693
dc.language.isoenges_ES
dc.publisherElsevier Sciencees_ES
dc.relation440:316-336
dc.relation.jnabreviadoNEUROSCIENCE
dc.relation.journalNeuroscience
dc.rightsAcceso Cerradoes_ES
dc.subject.kwChronic mild stress
dc.subject.kwCitalopram
dc.subject.kwDoublecortin
dc.subject.kwHippocampal neurogenesis
dc.subject.kwMelatonin
dc.subject.kwMicroglia
dc.titleMelatonin reverses the depression-associated behaviour and regulates microglia, fractalkine expression and neurogenesis in adult mice exposed to chronic mild stresses_ES
dc.typeArtículoes_ES

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