Synergistic interaction in the analgesic-like effects of maqui berry and citrus is antagonized by sweeteners

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dc.contributor.affiliationLaboratorio de Neurofarmacología de Productos Naturales, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calz. Mexico-Xochimilco 101, Col. San Lorenzo Huipulco, Tlalpan, Ciudad de Mexico 14370, Mexico
dc.contributor.emailevag@imp.edu.mx (M.E.G.-T.); cgviguera@cebas.csic.es (C.G.-V.)
dc.creatorAgulló, Vicentees_ES
dc.creatorGonzález-Trujano, María Evaes_ES
dc.creatorHernandez-Leon, Albertoes_ES
dc.creatorEstrada-Camarena, Erikaes_ES
dc.creatorPellicer, Franciscoes_ES
dc.creatorGarcía-Viguera, Cristinaes_ES
dc.creator.identificadorhttps://orcid.org/0000-0002-4399-1508 (González-Trujano, María Eva)
dc.creator.identificadorhttps://orcid.org/0000-0002-6864-6735 (Hernandez-Leon, Alberto)
dc.creator.identificadorttps://orcid.org/0000-0001-6634-7494 (Estrada-Camarena, Erika)
dc.creator.identificadorhttps://orcid.org/0000-0002-4751-3917 (García-Viguera, Cristina)
dc.date2021
dc.date.accessioned2024-05-31T17:11:31Z
dc.date.accessioned2026-03-27T15:30:09Z
dc.date.available2024-05-31T17:11:31Z
dc.date.issued2021
dc.date.published2021
dc.descriptionAlthough physiologically pain has a protective function, in many diseases, it is one of the most prominent symptoms. Today, new trends are focused on finding more natural alternatives to conventional treatments to alleviate it. Thereby, the purpose of this investigation was to obtain preclinical data of the antinociceptive properties of a lyophilized obtained from a newly designed maqui-citrus beverage alone and added with different sweeteners. To achieve this objective, maqui berry and citrus pharmacological activity were studied separately, as well as the interaction of both ingredients. In addition, due to the controversy generated regarding the intake of sugars, related to different metabolic diseases, the influence of different sweeteners (stevia, sucralose, or sucrose) was studied to determine their possible influence on the bioactive compounds of this product. For the attainment of our goals, a pharmacological evaluation, using the 1% formalin test, a nociceptive pain model in mice, was performed by using a sub-efficacious dosage of Maqui (25 mg/kg, i.p.) alone and combined with citrus, and then compared with the effects obtained in the presence of the different sweeteners. As a result, the antinociceptive response of the maqui was synergized in the presence of citrus in the neurogenic and inflammatory phases of the formalin test. However, this response was partially or totally reduced in the presence of the sweeteners. Our study gives preclinical evidence that a combination of maqui and citrus might exert beneficial actions to relieve pain, whereas the presence of sweeteners could reduce or avoid it.es_ES
dc.formatPDFes_ES
dc.identifierJC12NC21es_ES
dc.identifier.doi10.3390/nu13072466
dc.identifier.eissn2072-6643
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.placeSuiza
dc.identifier.urihttps://doi.org/10.3390/nu13072466
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/7984
dc.language.isoenges_ES
dc.publisherMDPI Publishinges_ES
dc.relation13(7):2466
dc.relation.jnabreviadoNUTRIENTS
dc.relation.journalNutrients
dc.rightsAcceso Cerradoes_ES
dc.subject.kwAnthocyanins
dc.subject.kwAntinociception
dc.subject.kwCitrus
dc.subject.kwPolyphenolic compounds
dc.subject.kwSweeteners
dc.titleSynergistic interaction in the analgesic-like effects of maqui berry and citrus is antagonized by sweetenerses_ES
dc.typeArtículoes_ES

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