Effects of intermittent fasting on hypothalamus-pituitary-thyroid axis, palatable food intake, and body weight in stressed rats

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dc.contributor.affiliationLaboratorio de Neurofisiología Molecular, Departamento de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Mexico City 14370, Mexico
dc.contributor.emailgortari@imp.edu.mx (Patricia de Gortari)
dc.creatorGarcía-Luna, Cinthiaes_ES
dc.creatorPrieto, Ixcheles_ES
dc.creatorSoberanes-Chávez, Paulinaes_ES
dc.creatorAlvarez-Salas, Elenaes_ES
dc.creatorTorre-Villalvazo, Ivánes_ES
dc.creatorMatamoros-Trejo, Gilbertoes_ES
dc.creatorGortari, Patricia dees_ES
dc.date2023
dc.date.accessioned2025-03-10T19:37:23Z
dc.date.accessioned2026-03-27T15:31:14Z
dc.date.available2025-03-10T19:37:23Z
dc.date.issued2023
dc.date.published2023
dc.descriptionDietary regimens that are focused on diminishing total caloric intake and restricting palatable food ingestion are the most common strategies for weight control. However, restrictive diet therapies have low adherence rates in obese patients, particularly in stressed individuals. Moreover, food restriction downregulates the hypothalamic-pituitary-thyroid axis (HPT) function, hindering weight loss. Intermittent fasting (IF) has emerged as an option to treat obesity. We compared the effects of IF to an all-day feeding schedule on palatable diet (PD)-stress (S)-induced hyperphagia, HPT axis function, accumbal thyrotropin-releasing hormone (TRH), and dopamine D2 receptor expression in association with adipocyte size and PPARƔ coactivator 1α (PGC1α) and uncoupling protein 1 (UCP1) expression in stressed vs. non-stressed rats. After 5 weeks, S-PD rats showed an increased energy intake and adipocyte size, fewer beige cells, and HPT axis deceleration-associated low PGC1α and UCP1 expression, as well as decreased accumbal TRH and D2 expression. Interestingly, IF reversed those parameters to control values and increased the number of beige adipocytes, UCP1, and PGC1α mRNAs, which may favor a greater energy expenditure and a reduced body weight, even in stressed rats. Our results showed that IF modulated the limbic dopaminergic and TRHergic systems that regulate feeding and HPT axis function, which controls the metabolic rate, supporting this regimen as a suitable non-pharmacologic strategy to treat obesity, even in stressed individuals.es_ES
dc.formatPDFes_ES
dc.identifierJC03NC23es_ES
dc.identifier.doi10.3390/nu15051164
dc.identifier.eissn2072-6643
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.placeSuiza
dc.identifier.urihttps://doi.org/10.3390/nu15051164
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/8235
dc.language.isoenges_ES
dc.publisherMDPI Publishinges_ES
dc.relation15(5):1164
dc.relation.jnabreviadoNUTRIENTS
dc.relation.journalNutrients
dc.rightsAcceso Cerradoes_ES
dc.subject.kwThyroid axis
dc.subject.kwIntermittent fasting
dc.subject.kwStress
dc.subject.kwOverweight
dc.subject.kwPalatable food
dc.titleEffects of intermittent fasting on hypothalamus-pituitary-thyroid axis, palatable food intake, and body weight in stressed ratses_ES
dc.typeArtículoes_ES

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