Salvia divinorum: from recreational hallucinogenic use to analgesic and anti-inflammatory action

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dc.contributor.affiliationResearch in Neurosciences, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Mexico City, México
dc.contributor.emailpellicer@imp.edu.mx (Francisco Pellicer)
dc.creatorCoffeen, Uliseses_ES
dc.creatorPellicer, Franciscoes_ES
dc.date2019
dc.date.accessioned2022-12-09T19:30:32Z
dc.date.accessioned2026-03-27T15:25:34Z
dc.date.available2022-12-09T19:30:32Z
dc.date.issued2019
dc.date.published2019
dc.descriptionSalvia divinorum is a herbal plant native to the southwest region of Mexico. Traditional preparations of this plant have been used in illness treatments that converge with inflammatory conditions and pain. Currently, S. divinorum extracts have become popular in several countries as a recreational drug due to its hallucinogenic effects. Its main active component is a diterpene named salvinorin A (SA), a potent naturally occurring hallucinogen with a great affinity to the κ opioid receptors and with allosteric modulation of cannabinoid type 1 receptors. Recent biochemical research has revealed the mechanism of action of the anti-inflammatory and analgesic effect of SA at the cellular and molecular level. Nevertheless, because of their short-lasting and hallucinogenic effect, the research has focused on discovering a new analogue of SA that is able to induce analgesia and reduce inflammation with a long-lasting effect but without the hallucinatory component. In this review, we explore the role of S. divinorum, SA and its analogues. We focus mainly on their analgesic and anti-inflammatory roles but also mention their psychoactive properties.es_ES
dc.formatPDFes_ES
dc.identifierJC26NC22es_ES
dc.identifier.doi10.2147/JPR.S188619
dc.identifier.eissn1178-7090
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.placeNueva Zelanda
dc.identifier.urihttps://doi.org/10.2147/JPR.S188619
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/7649
dc.language.isoenges_ES
dc.publisherDove Medical Presses_ES
dc.relation12:1069 -1076
dc.relation.jnabreviadoJ PAIN RES
dc.relation.journalJournal of Pain Research
dc.rightsAcceso Cerradoes_ES
dc.subject.kwSalvia divinorum
dc.subject.kwSalvinorin A
dc.subject.kwPain
dc.subject.kwInflammation
dc.subject.kwPsychoactivity
dc.titleSalvia divinorum: from recreational hallucinogenic use to analgesic and anti-inflammatory actiones_ES
dc.typeArtículoes_ES

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