Interaction of desipramine with steroid hormones on experimental anxiety

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dc.contributor.affiliationDepartamento de Farmacología, Sección de Terapéutica Experimental, CINVESTAV, Mexico D.F., Mexico.es_ES
dc.contributor.emailfegu@neuroserver.imp-neuro.edu.mxes_ES
dc.creatorMartínez-Mota, Lucía
dc.creatorEstrada-Camarena, Erika
dc.creatorLópez-Rubalcava, Carolina
dc.creatorContreras, Carlos M.
dc.creatorFernández-Guasti, Alonso
dc.creator.identificador"MAML700524MVZRTC06">Martínez Mota, Lucia Albaes_ES
dc.date.accessioned2017-06-29T04:24:32Z
dc.date.accessioned2026-03-27T14:35:25Z
dc.date.available2017-06-29T04:24:32Z
dc.date.issued2000es_ES
dc.date.published2000es_ES
dc.description.abstractotrodiomaThe present study analyzes if estradiol benzoate and-or progesterone interact with desmethylimipramine (DMI) to diminish experimental anxiety. The animal model of anxiety used was the conditioned defensive burying test. Dose response curves for DMI (0.625, 1.25 and 2.5 mg-kg, every 24 h, during 21 days), estradiol benzoate (0.5, 1.0, 2.0 and 4.0 micrograms-rat, 48 h) and progesterone (0.5, 1.0 and 2.0 mg-rat, -4 h) were made in ovariectomized rats. DMI per se decreased dose dependently the cumulative burying time, an effect considered as anxiolytic-like. Progesterone produced a decrease in burying at the highest dose, while estradiol benzoate had no effect on defensive burying. Both, progesterone (0.5 mg-rat) and estradiol benzoate (4.0 micrograms-rat) were able to decrease the cumulative burying behavior when injected with a subthreshold dose of DMI (1.25 mg-kg). In addition, the effect of DMI (1.25 mg-kg) plus the combination of estradiol benzoate and progesterone, sequentially administered (48 h and 4 h before the tests, respectively), also produced a synergistic decrease in burying behavior. In general, the treatments produced no changes in burying behavior latency, neither in spontaneous ambulation or in nociception. It is concluded that DMI synergizes its anxiolytic-like effect when administered with estradiol alone or in combination with progesterone. Present data provide experimental evidence suggesting an interaction between hormones and antidepressants. Results are discussed on the basis of the interaction between steroids and serotonergic or GABAergic receptorses_ES
dc.description.monthFebes_ES
dc.identifier317es_ES
dc.identifier.citationJuan Carlos Bautista Ramírezes_ES
dc.identifier.doi10.1016/S0306-4530(99)00042-6es_ES
dc.identifier.eissn1873-3360es_ES
dc.identifier.issn0306-4530es_ES
dc.identifier.numero2es_ES
dc.identifier.organizacionInstituto Mexicano de Psiquiatríaes_ES
dc.identifier.paginacion109-120es_ES
dc.identifier.placeInglaterraes_ES
dc.identifier.urihttps://doi.org/10.1016/S0306-4530(99)00042-6es_ES
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/5010
dc.identifier.volumen25es_ES
dc.language.isoenges_ES
dc.relation25 (2) 109-120 p.es_ES
dc.relationversión del editores_ES
dc.relation.jnabreviadoPSYCHONEUROENDOCRINOLOGYes_ES
dc.relation.journalPsychoneuroendocrinologyes_ES
dc.rightsacceso cerradoes_ES
dc.subject.kwAnimaleses_ES
dc.subject.kwAgentes antidepresivos-Farmacologíaes_ES
dc.subject.kwAnsiedad-Terapia farmacológicaes_ES
dc.subject.kwAnsiedad-Psicologíaes_ES
dc.subject.kwComportamiento Animal-Efectos de Drogases_ES
dc.subject.kwDesipramina-Farmacologíaes_ES
dc.subject.kwDosis-Respuesta a Drogaes_ES
dc.subject.kwEstradiol-Análogos y derivadoses_ES
dc.subject.kwEstradiol-Farmacologíaes_ES
dc.subject.kwFemeninoes_ES
dc.subject.kwActividad motora-Efectos de fármacoses_ES
dc.subject.kwOvariectomíaes_ES
dc.subject.kwMedición del dolor-Efectos de fármacoses_ES
dc.subject.kwProgesterona-Phamacologyes_ES
dc.subject.kwRatases_ES
dc.subject.kwRatas Wistares_ES
dc.subject.kwEsteroides-Farmacologíaes_ES
dc.subject.kwAgentes ntidepresivoses_ES
dc.subject.kwEsteroideses_ES
dc.subject.kwEstradiol 3-Benzoatoes_ES
dc.subject.kwEstradioles_ES
dc.subject.kwDesipraminaes_ES
dc.subject.kwProgesteronaes_ES
dc.subject.meshAnimalses_ES
dc.subject.meshAntidepressive Agents-Pharmacologyes_ES
dc.subject.meshAnxiety-Drug therapyes_ES
dc.subject.meshAnxiety-Psychologyes_ES
dc.subject.meshBehavior, Animal-Drug effectses_ES
dc.subject.meshDesipramine-Pharmacologyes_ES
dc.subject.meshDose-Response Relationship, Druges_ES
dc.subject.meshEstradiol-Analogs & derivativeses_ES
dc.subject.meshEstradiol-Pharmacologyes_ES
dc.subject.meshFemalees_ES
dc.subject.meshMotor Activity-Drug effectses_ES
dc.subject.meshOvariectomyes_ES
dc.subject.meshPain Measurement-Drug effectses_ES
dc.subject.meshProgesterone-Phamacologyes_ES
dc.subject.meshRatses_ES
dc.subject.meshRats, Wistares_ES
dc.subject.meshSteroids-Pharmacologyes_ES
dc.subject.meshAntidepressive Agentses_ES
dc.subject.meshSteroidses_ES
dc.subject.meshEstradiol 3-benzoatees_ES
dc.subject.meshEstradioles_ES
dc.subject.meshDesipraminees_ES
dc.subject.meshProgesteronees_ES
dc.titleInteraction of desipramine with steroid hormones on experimental anxietyes_ES
dc.typearticlees_ES

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