Experimental Pulmonary Tuberculosis in the Absence of Detectable Brain Infection Induces Neuroinflammation and Behavioural Abnormalities in Male BALB/c Mice

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dc.contributor.affiliationSección de Patología Experimental, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, CDMX 14080, Mexico.
dc.contributor.emailbrenda.marquinac@incmnsz.mx (B.M.-C.); rhdezpando@hotmail.com (R.H.-P.)
dc.creatorLara-Espinosa, Jacqueline V.es_ES
dc.creatorSantana-Martínez, Ricardo A.es_ES
dc.creatorMaldonado, Perla D.es_ES
dc.creatorZetter, Marioes_ES
dc.creatorBecerril-Villanueva, Enriquees_ES
dc.creatorPérez-Sánchez, Gilbertoes_ES
dc.creatorPavón, Lenines_ES
dc.creatorMata-Espinosa, Dulcees_ES
dc.creatorBarrios-Payán, Jorgees_ES
dc.creatorLópez-Torres, Manuel O.es_ES
dc.creatorMarquina-Castillo, Brendaes_ES
dc.creatorHernández-Pando, Rogelioes_ES
dc.creator.identificadorhttps://orcid.org/0000-0001-7210-9775 (Becerril-Villanueva, Enrique)
dc.creator.identificadorhttps://orcid.org/0000-0002-6067-6868 (Pavón, Lenin)
dc.date2020
dc.date.accessioned2023-05-29T17:18:59Z
dc.date.accessioned2026-03-27T15:26:10Z
dc.date.available2023-05-29T17:18:59Z
dc.date.issued2020
dc.date.published2020
dc.descriptionTuberculosis (TB) is a chronic infectious disease in which prolonged, non-resolutive inflammation of the lung may lead to metabolic and neuroendocrine dysfunction. Previous studies have reported that individuals coursing pulmonary TB experience cognitive or behavioural changes; however, the pathogenic substrate of such manifestations have remained unknown. Here, using a mouse model of progressive pulmonary TB, we report that, even in the absence of brain infection, TB is associated with marked increased synthesis of both inflammatory and anti-inflammatory cytokines in discrete brain areas such as the hypothalamus, the hippocampal formation and cerebellum accompanied by substantial changes in the synthesis of neurotransmitters. Moreover, histopathological findings of neurodegeneration and neuronal death were found as infection progressed with activation of p38, JNK and reduction in the BDNF levels. Finally, we perform behavioural analysis in infected mice throughout the infection, and our data show that the cytokine and neurochemical changes were associated with a marked onset of cognitive impairment as well as depressive- and anxiety-like behaviour. Altogether, our results suggest that besides pulmonary damage, TB is accompanied by an extensive neuroinflammatory and neurodegenerative state which explains some of the behavioural abnormalities found in TB patients.es_ES
dc.formatPDFes_ES
dc.identifierJC13NC20es_ES
dc.identifier.doi10.3390/ijms21249483
dc.identifier.eissn1422-0067
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.placeSuiza
dc.identifier.urihttps://doi.org/10.3390/ijms21249483
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7763936/
dc.identifier.urihttps://repositorio.inprf.gob.mx/handle/123456789/7701
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.relation21(24):9483
dc.relation.jnabreviadoINT J MOL SCI
dc.relation.journalInternational Journal of Molecular Sciences
dc.rightsAcceso Cerradoes_ES
dc.subject.kwMycobacterium tuberculosis
dc.subject.kwBehaviour abnormalities
dc.subject.kwNeuroinflammation
dc.titleExperimental Pulmonary Tuberculosis in the Absence of Detectable Brain Infection Induces Neuroinflammation and Behavioural Abnormalities in Male BALB/c Micees_ES
dc.typeArtículoes_ES

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