Browsing by Author "Ramírez-Salado, Ignacio"

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Amygdaloid neuronal activity changes during the sleep-wake cycle and phasic phenomena of REM sleep
(WILEY-BLACKWELL PUBLISHING, INC, COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA, 1998) Simón-Arceo, Karina; Ramírez-Salado, Ignacio; Calvo, José M.; Inst Mex Psiquiatria, Subdirecc Invest Neurociencias, Dept Etol, Antiguo Camino Xochimilco 101, Mexico City 14370, DF, Mexico.
Calea zacatechichi Schltdl. (Compositae) produces anxiolytic- and antidepressant-like effects, and increases the hippocampal activity during REM sleep in rodents
(Elsevier, 2021) Martinez-Mota, Lucía; Cruz-Tavera, Adrián; Dorantes-Barrón, Ana María; Arrieta-Báez, Daniel; Ramírez-Salado, Ignacio; Cruz-Aguilar, Manuel Alejandro; Mayagoitia-Novales, Lilian; Cassani, Julia; Estrada-Reyes, Rosa; Laboratorio de Farmacología Conductual, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría Ramón de La Fuente Muñiz, Calzada México-Xochimilco 101, Col. San Lorenzo Huipulco, Tlalpan, 14370, Ciudad de México, Mexico; restrada@imp.edu.mx (R. Estrada-Reyes)
Depressant effects of Salvia divinorum involve disruption of physiological sleep
(Wiley, 2016) González-Trujano, María Eva; Brindis, Fernando; López-Ruiz, Edith; Ramírez-Salado, Ignacio; Martínez, Adrián; Pellicer, Francisco; Laboratorio de Neurofarmacología de Productos Naturales, Dirección de Investigaciones en Neurociencias del Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calz. México-Xochimilco 101, Col. Sn. Lorenzo Huipulco14370, México, D. F., México; evag@imp.edu.mx (María Eva González-Trujano); pellicer@imp.edu.mx (Francisco Pellicer)
EEG coherence and power spectra during REM sleep related to melatonin intake in mild-to-moderate Alzheimer's disease: a pilot study
(Informa Healthcare, 2023) Cruz-Aguilar, Manuel Alejandro; Ramírez-Salado, Ignacio; Hernández-González, Marisela; Guevara, Miguel Angel; Rivera-García, Ana Paula; Laboratorio de Cronobiología y Sueño, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría "Ramón de la Fuente Muñiz," Ciudad de México, CDMX, México; macrag@gmail.com (Manuel Alejandro Cruz-Aguilar)
Efectos de la melatonina sobre la macro-arquitectura del sueño en pacientes con demencia tipo Alzheimer
(Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calz. México-Xochimilco 101, Col. San Lorenzo Huipulco, Tlalpan, México, D.F. Tel. 4160-5000., 2013) Cruz-Aguilar, Manuel Alejandro; Ramírez-Salado, Ignacio; Cruz-Ulloa, Carlos; Benítez-King, Gloria; Laboratorio de Sueno. Dirección de Investigación en Neurociencias. Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz.; macrag@gmail.com
El objetivo del presente estudio fue determinar los efectos de 5 mg. de melatonina de liberación inmediata sobre la macro-arquitectura del sueño en ocho pacientes con diagnostico de Demencia Tipo Alzheimer (DTA) de media a moderada. Utilizando la técnica polisomnográfica (PSG) se realizo un estudio simple ciego, no aleatorio, controlado con placebo. Los registros PSG se llevaron a cabo de la siguiente manera: Noche 1: administración de placebo; noche 2 y 3: administración continua de melatonina (5 mg). Observamos que el tratamiento con melatonina durante la primera noche de administración disminuyo significativamente la latencia de la fase 2, del sueño de ondas delta y el sueno de MOR al ser comparadas con el placebo (P =.05). No se observaron diferencias significativas en el tiempo total de cada fase de sueño; tampoco se observaron diferencias en la eficiencia del sueño en presencia de la melatonina. Sin embargo se observó una tendencia a la disminución del tiempo total de vigilia y un aumento del tiempo total de sueño, principalmente durante la segunda noche de tratamiento. Concluimos que la melatonina puede mejorar el sueno en pacientes con DTA de media a moderada.
Facial muscle activation during sleep and its relation to the rapid eye movements of REM sleep
(WILEY-BLACKWELL PUBLISHING, INC, COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA, 2011) Rivera-García, Ana Paula; Ramírez-Salado, Ignacio; Corsi-Cabrera, María; Calvo, José María; Inst Nacl Psiquiatria Ramon Fuente Muniz, Lab Sueno, Direcc Invest Neurociencias, Calz Mexico Xochimilco 101,Col Sn Lorenzo Huipulc, Mexico City 14370, DF, Mexico.; aprivera@imp.edu.mx
Facial muscle contractions (FMC) are a commonly observed feature during sleep stages in human subjects. Previous studies have associated FMC to emotional expression during waking. Phasic features of rapid eye movement (REM) sleep, such as REMs have also been linked to an increase in limbic structure activity with a subsequent relation to emotional dream content. We hypothesized that FMC would be more frequent during REM sleep, and that FMC would correlate with the characteristic REMs of this sleep stage. The present study was designed to evaluate the density per minute of the phasic and sustained FMC of five facial muscles (frontalis, corrugator, orbicularis oculi, zygomatic major left and right) during all sleep stages, and to explore their relation with REMs density in six healthy participants during an 8 h sleep recording. Results showed a significant increase in FMC of all recorded muscles during REM sleep, both in frequency and duration. Additionally, as expected, during REM sleep there was a positive correlation among the facial muscles and between these and REMs. Nevertheless, although associated in number, both features (FMC and REMs) were never simultaneous. Our results suggest that limbic activation during REM sleep may be responsible for the enhancement of facial muscle activity, which may be consistent with the theoretical perspective of a higher emotional activity during REM sleep.
Filogenia del sueño
(2009) Ramírez-Salado, Ignacio; Rivera-García, Ana Paula; Departamento de Cronobiología, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría "Ramón de la Fuente Muñiz", Calz. México-Xochimilco 101, Col. San Lorenzo Huipulco, C.P. 14370, México, D.F.
El estudio comparativo de los mecanismos fisiológicos del sueño es un campo reciente en la neurobiología. Aún es difícil afirmar si el sueño es una función biológica característica de todos los vertebrados o si sólo confinado a algunas clases representativas de aves y mamíferos. El sueño, como conducta, es un fenómeno universal. Sin embargo, los estudios electroencefalográficos realizados en organismos que carecen de una corteza desarrollada (e.g. tortugas, lagartos y peces) no han brindado información concluyente sobre los patrones polisomnográficos típicos de sueño. Los estudios evolutivos muestran que los animales de sangre fría no presentan ciclos de sueño y vigilia, sino simplemente transiciones cíclicas entre reposo y actividad determinadas por factores ambientales. El propósito del presente trabajo es dar a conocer las diferentes proporciones, características y patrones del fenómeno del sueño en diferentes especies.
GABAA receptor agonist at the caudo-lateral peribrachial area suppresses ponto-geniculo-occipital waves and its related states
(Tarrytown, NY : Elsevier, 2014) Ramírez-Salado, Ignacio; Rivera-García, Ana Paula; Velázquez Moctezuma, Javier; Jiménez Anguiano, Anabel; Pellicer, Francisco; Doctorado en Ciencias Biológicas y de la Salud, Universidad Autónoma Metropolitana-Iztapalapa, San Rafael Atlixco 186, Col. Vicentina, Iztapalapa, 09340, Mexico; Laboratorio de Cronobiología, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría "Ramón de la Fuente Muñiz", Calz. México-Xochimilco 101, Col. San Lorenzo Huipulco, Tlalpan, 14370, Mexico; salado@imp.edu.mx
Long-lasting enhancement of rapid eye movement sleep and pontogeniculooccipital waves by vasoactive intestinal peptide microinjection into the amygdala temporal lobe
(AMER ACAD SLEEP MEDICINE, 6301 BANDEL RD, STE 101, ROCHESTER, MN 55901 USA, 2003) Simón-Arceo, Karina; Ramírez-Salado, Ignacio; Calvo, José M.; Inst Nacl Psiquit Ramon de la Fuente, Div Invest Neurociencias, Dept Cronobiol, Caizada Mexico Xochimilco 101, Tlalpan 14370, Mexico.
Study Objectives: The effect of a vasoactive intestinal peptide (VIP) microinjection into the amygdaloid central (CN) and basal nuclei (BN) on sleep organization and on the number and pattern of occurrence of pontogeniculooccipital (PGO) waves was analyzed. Design: One group of 8 cats was studied in baseline conditions and after the microinjection of two doses of VIP applied into the CN and BN. Setting: Sleep research laboratory. Participants and Interventions: Eight cats were prepared with sleep-recording electrodes and with guide tubes in both amygdalae for saline and VIP microinjections. Neuropeptide doses of 0.10mug/1mul (30muM) and 0.33mug/1mu1 (99.24muM) were employed. Measurements and Results: Once the microinjection was applied, 23-hour polygraphic sleep recordings were performed for 5 consecutive days. Concomitantly the PGO waves were tape-recorded on each day and computationally analyzed. Results show that the 0.10mug/1mul microinjection produced no change. Unilateral VIP 0.33mug/1mul injection into the CN provoked a significant and lasting increase in the percentage of slow-wave sleep with PGO waves. Bilateral application of VIP increased the percentage of slow-wave sleep with PGO waves and rapid eye movement sleep for 5 days. Bilateral microinjection of the neuropeptide into the BN only enhanced the percentage of slow wave sleep with PGO waves. For both amygdaloid nuclei, we observed that VIP increased the number and modified the PGO wave pattern of occurrence during slow-wave sleep with PGO waves and during rapid eye movement sleep. Conclusions: The VIP microinjection into both the CN and BN induces increased amounts of rapid eye movement sleep, PGO waves, and slow-wave sleep with PGO waves, having a more robust effect on all of these three variables when applied into the CN.
Melatonin effects on EEG activity during non-rapid eye movement sleep in mild-to-moderate Alzheimer´s disease: a pilot study
(Informa Healthcare, 2021) Cruz-Aguilar, Manuel Alejandro; Ramírez-Salado, Ignacio; Hernández-González, Marisela; Guevara, Miguel Angel; Molina del Río, Jahaziel; Instituto Nacional de Psiquiatría "Ramón de la Fuente Muñiz," Dirección de Investigaciones en Neurociencias, Laboratorio de Cronobiología y Sueño, CDMX, México.; macrag@gmail.com (Manuel Alejandro Cruz-Aguilar)
Melatonin effects on EEG activity during sleep onset in mild-to-moderate alzheimer's disease: a pilot study
(IOS Press, 2018) Cruz-Aguilar, Manuel Alejandro; Ramírez-Salado, Ignacio; Guevara, Miguel Angel; Hernández-González, Marisela; Benitez-King, Gloria; Universidad de Guadalajara, Instituto de Neurociencias, CUCBA, Laboratorio de Correlación Electroencefalográfica y Conducta, Guadalajara, Jalisco, México; macrag@gmail.com (Manuel Alejandro Cruz-Aguilar)
New bands in the sleep stages of spider monkeys (Ateles geoffroyi): electroencephalographic correlations and spatial distribution
(Wiley-Blackwell, 2023) Hernández-Arteaga, Enrique; Cruz-Aguilar, Manuel A.; Hernández-González, Marisela; Guevara, Miguel A.; Ramírez-Salado, Ignacio; Rivera-García, Ana P.; Facultad de Ciencias para el Desarrollo Humano, Universidad Autónoma de Tlaxcala, Tlaxcala, México; macrag@gmail.com (Manuel A. Cruz‐Aguilar)
Principal component analysis of electroencephalographic activity during sleep and wakefulness in the spider monkey (Ateles geoffroyi)
(Wiley-Blackwell, 2020) Cruz-Aguilar, Manuel Alejandro; Hernández-Arteaga, Enrique; Hernández-González, Marisela; Ramírez-Salado, Ignacio; Guevara, Miguel Angel; Laboratorio de Cronobiología y Sueño, Instituto Nacional de Psiquiatría "Ramón de la Fuente Muñiz", Dirección de Investigaciones en Neurociencias, CDMX, México.; macrag@gmail.com (Manuel Alejandro Cruz-Aguilar)