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Spinal dopaminergic D1-and D2-like receptors have a sex-dependent effect in an experimental model of fibromyalgia

dc.creatorDe la Luz-Cuellar, Yarim Elidethes_ES
dc.creatorCoffeen, Uliseses_ES
dc.creatorMercado, Franciscoes_ES
dc.creatorGranados-Soto, Vinicioes_ES
dc.date2023
dc.date.accessioned2025-04-02T19:26:23Z
dc.date.available2025-04-02T19:26:23Z
dc.date.issued2023
dc.identifierJC15NC23es_ES
dc.identifier.issn0014-2999
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/8290
dc.identifier.urihttps://doi.org/10.1016/j.ejphar.2023.175696
dc.descriptionThere is evidence about the importance of sex in pain. The purpose of this study was to investigate the effect of sex in the antiallodynic activity of spinal dopamine D1-and D2-like receptors in a model of fibromyalgia-type pain in rats. Reserpine induced the same extent of tactile allodynia in female and male rats. Intrathecal injection of SCH-23390 (3-30 nmol, D1-like receptor antagonist), pramipexole (0.15-15 nmol) or quinpirole (1-10 nmol D2-like receptor agonists) increased withdrawal threshold in reserpine-treated female rats. Those drugs induced a greater antiallodynic effect in female rats. Sex-difference was also observed in a nerve injury model. Ovariectomy abated the antiallodynic effect of SCH-23390 (30 nmol) in reserpine-treated rats, while systemic reconstitution of 17β-estradiol levels or intrathecal injection of estrogen receptor-α agonist protopanaxatriol in ovariectomized reserpine-treated females restored the antiallodynic effect of SCH-23390. Intrathecal administration of ICI-182,780 (estrogen receptor-α/β antagonist) or methyl-piperidino-pyrazole hydrate (estrogen receptor-α antagonist) abated 17β-estradiol-restored antiallodynic effect of SCH-23390 in rats. In contrast, ovariectomy slightly reduced the effect of pramipexole (15 nmol) or quinpirole (10 nmol) in reserpine-treated rats, whereas systemic reconstitution of 17β-estradiol levels did not modify the antiallodynic effect of both drugs. Combination 17β-estradiol/progesterone, but not 17β-estradiol nor progesterone alone, restored the antiallodynic effect of pramipexole and quinpirole in the rats. Mifepristone (progesterone receptor antagonist) abated 17β-estradiol + progesterone restoration of the antiallodynic effect of pramipexole and quinpirole. These data suggest that the antiallodynic effect of dopamine D1-and D2-like receptors in fibromyalgia-type pain depends on spinal 17β-estradiol/estrogen receptor-α and progesterone receptors, respectively.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relation948:175696
dc.rightsAcceso Cerradoes_ES
dc.titleSpinal dopaminergic D1-and D2-like receptors have a sex-dependent effect in an experimental model of fibromyalgiaes_ES
dc.typeArtículoes_ES
dc.contributor.affiliationNeurobiology of Pain Laboratory, Departamento de Farmacobiología, Cinvestav, South Campus, Mexico City, Mexico
dc.contributor.emailvgranados@cinvestav.mx (V. Granados-Soto)
dc.relation.jnabreviadoEUR J PHARMACOL
dc.relation.journalEuropean Journal of Pharmacology
dc.identifier.placePaíses Bajos
dc.date.published2023
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1879-0712
dc.identifier.doi10.1016/j.ejphar.2023.175696
dc.subject.kwDopamine D(1)-like receptors
dc.subject.kwDopamine D(2)-like receptors
dc.subject.kwFibromyalgia
dc.subject.kwPain
dc.subject.kwReserpine


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