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Research evaluating the effectiveness of dementia interventions in low- and middle-income countries: A systematic mapping of 340 randomised controlled trials

dc.creatorSalcher-Konrad, Maximilianes_ES
dc.creatorShi, Chenges_ES
dc.creatorPatel, Dishaes_ES
dc.creatorMcDaid, Davides_ES
dc.creatorAstudillo-García‐ Claudia Ivethes_ES
dc.creatorBobrow, Kirstenes_ES
dc.creatorChoy, Jackyes_ES
dc.creatorComas-Herrera, Adelinaes_ES
dc.creatorFry, Andraes_ES
dc.creatorKnapp, Martines_ES
dc.creatorLeung, Dara Kiu Yies_ES
dc.creatorLopez-Ortega, Marianaes_ES
dc.creatorLorenz-Dant, Klaraes_ES
dc.creatorMusyimi, Christinees_ES
dc.creatorNdetei, Davides_ES
dc.creatorNguyen, Tuan Anhes_ES
dc.creatorOliveira, Deborahes_ES
dc.creatorPutra, Adityaes_ES
dc.creatorVara, Alishaes_ES
dc.creatorWong, Gloriaes_ES
dc.creatorNaci, Huseyines_ES
dc.creatorSTRiDE Evidence Review Groupes_ES
dc.date2023
dc.date.accessioned2025-04-01T20:04:31Z
dc.date.available2025-04-01T20:04:31Z
dc.date.issued2023
dc.identifierJC45DIEP23es_ES
dc.identifier.issn0885-6230
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/8287
dc.identifier.urihttps://doi.org/10.1002/gps.5965
dc.descriptionObjectives: More people with dementia live in low- and middle-income countries (LMICs) than in high-income countries, but best-practice care recommendations are often based on studies from high-income countries. We aimed to map the available evidence on dementia interventions in LMICs. Methods: We systematically mapped available evidence on interventions that aimed to improve the lives of people with dementia or mild cognitive impairment (MCI) and/or their carers in LMICs (registered on PROSPERO: CRD42018106206). We included randomised controlled trials (RCTs) published between 2008 and 2018. We searched 11 electronic academic and grey literature databases (MEDLINE, EMBASE, PsycINFO, CINAHL Plus, Global Health, World Health Organization Global Index Medicus, Virtual Health Library, Cochrane CENTRAL, Social Care Online, BASE, MODEM Toolkit) and examined the number and characteristics of RCTs according to intervention type. We used the Cochrane risk of bias 2.0 tool to assess the risk of bias. Results: We included 340 RCTs with 29,882 (median, 68) participants, published 2008-2018. Over two-thirds of the studies were conducted in China (n = 237, 69.7%). Ten LMICs accounted for 95.9% of included RCTs. The largest category of interventions was Traditional Chinese Medicine (n = 149, 43.8%), followed by Western medicine pharmaceuticals (n = 109, 32.1%), supplements (n = 43, 12.6%), and structured therapeutic psychosocial interventions (n = 37, 10.9%). Overall risk of bias was judged to be high for 201 RCTs (59.1%), moderate for 136 (40.0%), and low for 3 (0.9%). Conclusions: Evidence-generation on interventions for people with dementia or MCI and/or their carers in LMICs is concentrated in just a few countries, with no RCTs reported in the vast majority of LMICs. The body of evidence is skewed towards selected interventions and overall subject to high risk of bias. There is a need for a more coordinated approach to robust evidence-generation for LMICs.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherJohn Wileyes_ES
dc.relation38(7):e5965
dc.rightsAcceso Cerradoes_ES
dc.titleResearch evaluating the effectiveness of dementia interventions in low- and middle-income countries: A systematic mapping of 340 randomised controlled trialses_ES
dc.typeArtículoes_ES
dc.contributor.affiliationCare Policy and Evaluation Centre (CPEC), Department of Health Policy, London School of Economics and Political Science, London, UK
dc.contributor.emailmaximilian.salcher@goeg.at, m.salcher@lse.ac.uk (Maximilian Salcher‐Konrad)
dc.relation.jnabreviadoINT J GERIATR PSYCHIATRY
dc.relation.journalInternational Journal of Geriatric Psychiatry
dc.identifier.placeInglaterra
dc.date.published2023
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de Fuente Muñiz
dc.identifier.eissn1099-1166
dc.identifier.doi10.1002/gps.5965
dc.subject.kwDementia
dc.subject.kwEvidence
dc.subject.kwGlobal south
dc.subject.kwHealth policy
dc.subject.kwLMIC
dc.subject.kwLow‐ and middle‐income
dc.subject.kwPsychosocial interventions
dc.subject.kwSystematic review
dc.subject.kwTraditional Chinese medicine


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