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Two murine models of sepsis: immunopathological diferences between the sexes—possible role of TGFβ1 in female resistance to endotoxemia

dc.creatorBojalil, Rafaeles_ES
dc.creatorRuíz-Hernández, Armandoes_ES
dc.creatorVillanueva-Arias, Arturoes_ES
dc.creatorAmezcua-Guerra, Luis Manueles_ES
dc.creatorCásarez-Alvarado, Sergioes_ES
dc.creatorHernández-Dueñas, Ana Maríaes_ES
dc.creatorRodríguez-Galicia, Verónicaes_ES
dc.creatorPavón, Lenines_ES
dc.creatorMarquina, Brendaes_ES
dc.creatorBecerril-Villanueva, Enriquees_ES
dc.creatorHernández-Pando, Rogelioes_ES
dc.creatorMárquez-Velasco, Ricardoes_ES
dc.date2023
dc.date.accessioned2025-03-18T19:50:52Z
dc.date.available2025-03-18T19:50:52Z
dc.date.issued2023
dc.identifierJC05NC23es_ES
dc.identifier.issn0716-9760
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/8253
dc.identifier.urihttps://doi.org/10.1186/s40659-023-00469-8
dc.descriptionEndotoxic shock (ExSh) and cecal ligature and puncture (CLP) are models that induce sepsis. In this work, we inves‑ tigated early immunologic and histopathologic changes induced by ExSh or CLP models in female and male mice. Remarkable results showed that females supported twice the LD100 of LPS for males, CLP survival and CFU counts were similar between genders, high circulating LPS levels in ExSh mice and low levels of IgM anti-LPS in males. In the serum of ExSh males, TNF and IL-6 increased in the frst 6 h, in CLP males at 12 h. In the liver of ExSh mice, TNF increased at 1.5 and 12 h, IL-1 at 6 h. TGFβ1 increased in females throughout the study and at 12 h in males. In CLP mice, IL-6 decreased at 12 h, TGFβ1 increased at 6–12 h in males and at 12 h in females. In the lungs of ExSh males, IL-1β increased at 1.5-6 h and TGFβ1 at 12 h; in females, TNF decrease at 6 h and TGFβ1 increased from 6 h; in CLP females, TNF and IL-1β decreased at 12 h and 1.5 h, respectively, and TGFβ1 increased from 6 h; in males, TGFβ1 increased at 12 h. In the livers of ExSh mice, signs of infammation were more common in males; in the CLP groups, infammation was similar but less pronounced. ExSh females had leucocytes with TGFβ1. The lungs of ExSh males showed patches of hyaline membranes and some areas of infammatory cells, similar but fewer and smaller lesions were seen in male mice with CLP. In ExSh females, injuries were less extent than in males, similar pulmonary lesions were seen in female mice with CLP. ExSh males had lower levels of TGFβ1 than females, and even lower levels were seen in CLP males. We conclude that the ExSh was the most lethal model in males, associated with high levels of free LPS, low IgM anti-LPS, exacerbated infammation and target organ injury, while females showed early TGFβ1 produc‑ tion in the lungs and less tissue damage. We didn’t see any diferences between CLP mice.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherBiomed Centrales_ES
dc.relation56:54
dc.rightsAcceso Cerradoes_ES
dc.titleTwo murine models of sepsis: immunopathological diferences between the sexes—possible role of TGFβ1 in female resistance to endotoxemiaes_ES
dc.typeArtículoes_ES
dc.contributor.affiliationDepartamento de Inmunología, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico
dc.contributor.emailmarquezric@hotmail.com (Ricardo Márquez‑Velasco)
dc.relation.jnabreviadoBIOL RES
dc.relation.journalBiological Research
dc.identifier.placeInglaterra
dc.date.published2023
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn0717-6287
dc.identifier.doi10.4067/s0716-97602003000300011


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