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New efforts to demonstrate the successful use of TRH as a therapeutic agent

dc.creatorAlvares-Salas, Elenaes_ES
dc.creatorGarcía-Luna, Cinthiaes_ES
dc.creatorGortari, Patricia dees_ES
dc.date2023
dc.date.accessioned2025-03-13T20:42:51Z
dc.date.available2025-03-13T20:42:51Z
dc.date.issued2023
dc.identifierJC35es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/8246
dc.identifier.urihttps://doi.org/10.3390/ijms241311047
dc.descriptionThyrotropin-releasing hormone (TRH) is a tripeptide that regulates the neuroendocrine thyroid axis. Moreover, its widespread brain distribution has indicated that it is a relevant neuromodulator of behaviors such as feeding, arousal, anxiety, and locomotion. Importantly, it is also a neurotrophic peptide, and thus may halt the development of neurodegenerative diseases and improve mood-related disorders. Its neuroprotective actions on those pathologies and behaviors have been limited due to its poor intestinal and blood-brain barrier permeability, and because it is rapidly degraded by a serum enzyme. As new strategies such as TRH intranasal delivery emerge, a renewed interest in the peptide has arisen. TRH analogs have proven to be safe in animals and humans, while not inducing alterations in thyroid hormones' levels. In this review, we integrate research from different approaches, aiming to demonstrate the therapeutic effects of TRH, and to summarize new efforts to prolong and facilitate the peptide's actions to improve symptoms and the progression of several pathologies.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.relation24(13):11047
dc.rightsAcceso Cerradoes_ES
dc.titleNew efforts to demonstrate the successful use of TRH as a therapeutic agentes_ES
dc.typeArtículoes_ES
dc.contributor.affiliationLaboratorio de Neurofisiología Molecular, Dirección de Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calzada México-Xochimilco 101, San Lorenzo Huipulco, Tlalpan, Mexico City CP 14370, Mexico
dc.contributor.emailgortari@imp.edu.mx
dc.relation.jnabreviadoINT J MOL SCI
dc.relation.journalInternational Journal of Molecular Sciences
dc.identifier.placeSuiza
dc.date.published2023
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1422-0067
dc.identifier.doi10.3390/ijms241311047
dc.subject.kwThyrotropin-releasing hormone
dc.subject.kwTherapeutic factor
dc.subject.kwNeuromodulator
dc.subject.kwTRH analogs


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