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Melatonin prevents depression but not anxiety-like behavior produced by the chemotherapeutic agent temozolomide: implication of doublecortin cells and hilar oligodendrocytes

dc.creatorCabrera-Muñoz, Edith Aracelies_ES
dc.creatorRamírez-Rodríguez, Gerardo Bernabées_ES
dc.creatorDíaz-Yañez, Lizethes_ES
dc.creatorReyes-Galindo, Verónicaes_ES
dc.creatorMeneses-San Juan, Davides_ES
dc.creatorVega-Rivera, Nelly Maritzaes_ES
dc.date2023
dc.date.accessioned2025-03-12T18:57:07Z
dc.date.available2025-03-12T18:57:07Z
dc.date.issued2023
dc.identifierJC04IC23es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/8244
dc.identifier.urihttps://doi.org/10.3390/ijms241713376
dc.descriptionMelatonin is a hormone synthesized by the pineal gland with neuroprotective and neurodevelopmental effects. Also, melatonin acts as an antidepressant by modulating the generation of new neurons in the dentate gyrus of the hippocampus. The positive effects of melatonin on behavior and neural development may suggest it is used for reverting stress but also for the alterations produced by chemotherapeutic drugs influencing behavior and brain plasticity. In this sense, temozolomide, an alkylating/anti-proliferating agent used in treating brain cancer, is associated with decreased cognitive functions and depression. We hypothesized that melatonin might prevent the effects of temozolomide on depression- and anxiety-like behavior by modulating some aspects of the neurogenic process in adult Balb/C mice. Mice were treated with temozolomide (25 mg/kg) for three days of two weeks, followed by melatonin (8 mg/kg) for fourteen days. Temozolomide produced short- and long-term decrements in cell proliferation (Ki67-positive cells: 54.89% and 53.38%, respectively) and intermediate stages of the neurogenic process (doublecortin-positive cells: 68.23% and 50.08%, respectively). However, melatonin prevented the long-term effects of temozolomide with the increased number of doublecortin-positive cells (47.21%) and the immunoreactivity of 2' 3'-Cyclic-nucleotide-3 phosphodiesterase (CNPase: 82.66%), an enzyme expressed by mature oligodendrocytes, in the hilar portion of the dentate gyrus. The effects of melatonin in the temozolomide group occurred with decreased immobility in the forced swim test (45.55%) but not anxiety-like behavior. Thus, our results suggest that melatonin prevents the harmful effects of temozolomide by modulating doublecortin cells, hilar oligodendrocytes, and depression-like behavior tested in the forced swim test. Our study could point out melatonin's beneficial effects for counteracting temozolomide's side effects.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherMDPIes_ES
dc.relation24(17):13376
dc.rightsAcceso Cerradoes_ES
dc.titleMelatonin prevents depression but not anxiety-like behavior produced by the chemotherapeutic agent temozolomide: implication of doublecortin cells and hilar oligodendrocyteses_ES
dc.typeArtículoes_ES
dc.contributor.affiliationLaboratorio de Neurogénesis, Subdirección de Investigaciones Clínicas, Instituto Nacional de Psiquiatría "Ramón de la Fuente Muñiz", Calzada Mexico-Xochimilco 101, Ciudad de México 14370, Mexico
dc.contributor.emailgbernabe@imp.edu.mx
dc.relation.jnabreviadoINT J MOL SCI
dc.relation.journalInternational Journal of Molecular Sciences
dc.identifier.placeSuiza
dc.date.published2023
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1422-0067
dc.identifier.doi10.3390/ijms241713376
dc.subject.kwMelatonin
dc.subject.kwTemozolomide
dc.subject.kwOligodendrocytes
dc.subject.kwHippocampus
dc.subject.kwDepression
dc.subject.kwAnxiety
dc.subject.kwAdult neurogenesis


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