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Is brain perfusion correlated to switching mood states and cognitive impairment in bipolar disorder type I? A longitudinal study using perfusion imaging approach

dc.creatorEstudillo-Guerra, Maria Anayalies_ES
dc.creatorLinnman, Clases_ES
dc.creatorGalvez, Victores_ES
dc.creatorChapa-Koloffon, Ginaes_ES
dc.creatorPacheco-Barrios, Kevines_ES
dc.creatorMorales-Quezada, Leones_ES
dc.creatorFlores Ramos, Monicaes_ES
dc.date2023
dc.date.accessioned2025-02-20T18:23:38Z
dc.date.available2025-02-20T18:23:38Z
dc.date.issued2023
dc.identifierJC03IC23es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/8221
dc.identifier.urihttps://doi.org/10.3389/fpsyt.2023.1244134
dc.descriptionType I Bipolar disorder (BD-I) is a neuropsychiatric disorder characterized by manic or mixed-featured episodes, impaired cognitive functioning, and persistent work and social functioning impairment. This study aimed to investigate within-subject; (i) differences in brain perfusion using Single-photon emission computed tomography (SPECT) between manic and euthymic states in BD-I patients; (ii) explore potential associations between altered brain perfusion and cognitive status; and (iii) examine the relationship between cerebral perfusion and mania symptom ratings. Seventeen adult patients diagnosed with BD-I in a manic episode were recruited, and clinical assessments, cognitive tests, and brain perfusion studies were conducted at baseline (mania state) and a follow-up visit 6 months later. The results showed cognitive impairment during the manic episode, which persisted during the euthymic state at follow-up. However, no significant changes in brain perfusion were observed between the manic and euthymic states. During mania, trends toward decreased perfusion in the left cerebellum and right superior parietal lobule were noted. Additionally, trends indicated a higher perfusion imbalance in the left superior and middle frontal gyrus during mania and the right superior and middle frontal gyrus during euthymia. No significant correlations existed between brain perfusion, mania symptom ratings, and cognitive performance, indicating that symptomatology might represent more than neural hemodynamics. These findings suggest that cognitive impairment may persist in BD-I patients and highlight the need for therapeutic interventions targeting cognitive deficits. More extensive studies with extended follow-up periods are warranted further to investigate brain perfusion and cognitive functioning in BD-I patients.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherSuizaes_ES
dc.relation14:1244134
dc.rightsAcceso Cerradoes_ES
dc.titleIs brain perfusion correlated to switching mood states and cognitive impairment in bipolar disorder type I? A longitudinal study using perfusion imaging approaches_ES
dc.typeArtículoes_ES
dc.contributor.affiliationClínica de Trastornos del Afecto, Instituto Nacional de Psiquiatría "Ramón de la Fuente", Mexico City, Mexico
dc.contributor.emailmonica.flores@imp.edu.mx (Monica Flores Ramos)
dc.relation.jnabreviadoFRONT PSYCHIATRY
dc.relation.journalFrontiers in Psychiatry
dc.identifier.placeSuiza
dc.date.published2023
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1664-0640
dc.identifier.doi10.3389/fpsyt.2023.1244134
dc.subject.kwBipolar disorder
dc.subject.kwSPECT
dc.subject.kwBrain imaging
dc.subject.kwCognitive function
dc.subject.kwNeuroimaging
dc.subject.kwNuclear medicine


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