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Tabernaemontana arborea and ibogaine induce paroxysmal EEG activity in freely moving mice: Involvement of serotonin 5-HT1A receptors

dc.creatorGonzález-Trujano, María Evaes_ES
dc.creatorKrengel, Felixes_ES
dc.creatorReyes-Chilpa, Ricardoes_ES
dc.creatorVillasana-Salazar, Benjamínes_ES
dc.creatorGonzález-Gómez, José Davides_ES
dc.creatorSantos-Valencia, Fernandoes_ES
dc.creatorUrbina-Trejo, Edgares_ES
dc.creatorMartínez, Adriánes_ES
dc.creatorMartínez-Vargas, Davides_ES
dc.date2022
dc.date.accessioned2024-12-16T19:47:53Z
dc.date.available2024-12-16T19:47:53Z
dc.date.issued2022
dc.identifierJC19NC22es_ES
dc.identifier.issn0161-813X
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/8162
dc.identifier.urihttps://doi.org/10.1016/j.neuro.2022.01.002
dc.descriptionSeveral Apocynaceae species, most notably Tabernanthe iboga, Voacanga africana and many Tabernaemontana species, produce ibogan-type alkaloids. Although a large amount of information exists about the Tabernaemontana genus, knowledge concerning chemistry and biological activity remains lacking for several species, especially related to their effects on the central nervous system (CNS). The aim of this study was to evaluate the effect of Tabernaemontana arborea Rose ex J.D.Sm. (T. arborea) hydroalcoholic extract (30, 56.2 and 100 mg/kg, i.p.) and two of its main alkaloids (ibogaine and voacangine, 30 mg/kg, i.p.) on electroencephalographic (EEG) activity alone and in the presence of the chemical convulsant agent pentylenetetrazole (PTZ, 85 mg/kg, i.p.) in mice. EEG spectral power analysis showed that T. arborea extract (56.2 and 100 mg/kg) and ibogaine (30 mg/kg, i.p.) promoted a significant increase in the relative power of the delta band and a significant reduction in alpha band values, denoting a CNS depressant effect. Voacangine (30 mg/kg, i.p.) provoked an EEG flattening pattern. The PTZ-induced seizures were not modified in the presence of T. arborea, ibogaine, or voacangine. However, sudden death was observed in mice treated with T. arborea extract at 100 mg/kg, i.p., combined with PTZ. Because T. arborea extract (100 mg/kg, i.p.) and ibogaine (30 mg/kg, i.p.), but not voacangine (30 mg/kg, i.p.), induced paroxysmal activity in the EEG, both were explored in the presence of a serotonin 5-HT1A receptor antagonist (WAY100635, 1 mg/kg, i.p.). The antagonist abolished the paroxysmal activity provoked by T. arborea (100 mg/kg, i.p.) but not that observed with ibogaine, corroborating the participation of serotonin neurotransmission in the T. arborea effects. In conclusion, high doses of the T. arborea extract induced abnormal EEG activity due in part to the presence of ibogaine and involving serotonin 5-HT1A receptor participation. Nevertheless, other possible constituents and mechanisms might participate in this complex excitatory activity that would be interesting to explore in future studies.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.relation89:79-91
dc.rightsAcceso Cerradoes_ES
dc.titleTabernaemontana arborea and ibogaine induce paroxysmal EEG activity in freely moving mice: Involvement of serotonin 5-HT1A receptorses_ES
dc.typeArtículoes_ES
dc.contributor.affiliationLaboratorio de Neurofarmacología de Productos Naturales, Dirección de Investigaciones en Neurociencias, Instituto Nacional de Psiquiatría "Ramón de la Fuente Muñiz", Calz. México-Xochimilco 101, Col. San Lorenzo Huipulco, 14370, Ciudad de México, Mexico
dc.contributor.emailevag@imp.edu.mx (M.E. Gonzalez-Trujano), 40949009@ciencias.unam.mx (F. Krengel), chilpa@unam.mx (R. Reyes-Chilpa), benvillasanasalazar@gmail.com (B. Villasana-Salazar), david.gomez.psi@gmail.com (J.D. González-Gómez), psicfernandosv@gmail.com (F. Santos-Valencia), eurbinat@gmail.com (E. Urbina-Trejo), adrianmc@imp.edu.mx (A. Martínez), davmv@imp.edu.mx (D. Martínez-Vargas)
dc.relation.jnabreviadoNEUROTOXICOLOGY
dc.relation.journalNeurotoxicology
dc.identifier.placePaíses Bajos
dc.date.published2022
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1872-9711
dc.identifier.doi10.1016/j.neuro.2022.01.002
dc.subject.kwEEG
dc.subject.kwIbogaine
dc.subject.kwVoacangine
dc.subject.kw5-HT1A
dc.subject.kwSeizures


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