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Pomegranate and its components, punicalagin and ellagic acid, promote antidepressant, antioxidant, and free radical-scavenging activity in ovariectomized rats

dc.creatorCervantes-Anaya, Nancyes_ES
dc.creatorAzpilcueta-Morales, Gabrieles_ES
dc.creatorEstrada-Camarena, Erikaes_ES
dc.creatorRamírez Ortega, Danielaes_ES
dc.creatorPérez de la Cruz, Veronicaes_ES
dc.creatorGonzález-Trujano, Maria Evaes_ES
dc.creatorLópez-Rubalcava, C.es_ES
dc.date2022
dc.date.accessioned2024-12-11T19:22:48Z
dc.date.available2024-12-11T19:22:48Z
dc.date.issued2022
dc.identifierJC14NC22es_ES
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/8156
dc.identifier.urihttps://doi.org/10.3389/fnbeh.2022.836681
dc.descriptionPrevious reports described the antidepressant-like action of the aqueous extract of pomegranate (Punica granatum: AEPG). Thus we evaluated the effect of AEPG and the main compounds found in the extract, punicalagin (PNCG) and ellagic acid (EA), on forced swimming test and the redox environment (reactive oxygen species [ROS] production, lipoperoxidation [LPX], and cellular function) in the brain of rats treated with 3 weeks post ovariectomy exposed ex vivo to pro-oxidants. Also, we selected PNCG and EA to study their antidepressant-like effects (0.001, 0.01, 0.1, 1.0, and 10 mg/kg) in the forced swimming test and their scavenging capacities in chemical combinatorial assays (expressed as IC50 values). We observed a 2-fold increase in the formation of ROS and LPX in the brain after exposure to FeSO4. However, these effects were significantly attenuated when rats were treated with AEPG, PNCG, and EA (1 mg/kg and 0.010 mg/kg for 14 days). AEPG and EA significantly increased the cellular function values of brains that had been affected by the effect of FeSO4 and with ONOO-. PNCG and EA significantly reduced immobility behavior at the lower doses used in this study. The capacity of scavenging compounds to eliminate radicals was for hydroxyl radical (⋅OH), superoxide anion (O2⋅⁣-), and peroxynitrite (ONOO-) as follows: AEPG > punicalagin > ellagic acid. In conclusion, the AEPG and their active compounds PNCG and EA promote antidepressant-like actions and antioxidant activity as they attenuate oxidative damage and prevent cellular dysfunction in ovariectomized rat brains.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherFrontiers Research Foundationes_ES
dc.relation16:836681
dc.rightsAcceso Cerradoes_ES
dc.titlePomegranate and its components, punicalagin and ellagic acid, promote antidepressant, antioxidant, and free radical-scavenging activity in ovariectomized ratses_ES
dc.typeArtículoes_ES
dc.contributor.affiliationLaboratorio de Neuropsicofarmacología, Dirección de Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Secretaria de Salud (SSA), Mexico City, Mexico
dc.contributor.emailestrada@imp.edu.mx (Erika Estrada-Camarena)
dc.relation.jnabreviadoFRONT BEHAV NEUROSCI
dc.relation.journalFrontiers in Behavioral Neuroscience
dc.identifier.placeSuiza
dc.date.published2022
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1662-5153
dc.identifier.doi10.3389/fnbeh.2022.836681
dc.subject.kwAntioxidant
dc.subject.kwAntidepressant-like effect
dc.subject.kwAqueous extract of Punica granatum (AEPG)
dc.subject.kwPunicalagin
dc.subject.kwEllagic acid
dc.subject.kwOvariectomy
dc.subject.kwFree radical-scavenging activity
dc.subject.kwPomegranate


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