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Effects of post-ovariectomy time frame and age on the antidepressant-like actions of estradiol and prolame in female rats

dc.creatorHernández-Hernández, Olivia Taniaes_ES
dc.creatorHerrera-Pérez, José Jaimees_ES
dc.creatorChavira, Robertoes_ES
dc.creatorLemini, Cristinaes_ES
dc.creatorMartínez-Mota, Lucíaes_ES
dc.date2022
dc.date.accessioned2024-12-11T17:52:33Z
dc.date.available2024-12-11T17:52:33Z
dc.date.issued2022
dc.identifierJC11NC22es_ES
dc.identifier.issn0018-506X
dc.identifier.urihttp://repositorio.inprf.gob.mx/handle/123456789/8151
dc.identifier.urihttps://doi.org/10.1016/j.yhbeh.2022.105154
dc.descriptionEstrogen replacement therapy (ERT) is an effective treatment for symptoms associated with climacteric and depression some women experience during perimenopause and menopause. The antidepressant-like effects of ERT may depend on the type of estrogen, age, and time when restitution is initiated after hormonal decline. Prolame is a synthetic steroid with estrogenic and antidepressant-like effects that may produce fewer adverse effects. We hypothesize that such actions of prolame on females depend on age and the duration of hormone deprivation period. We assessed the antidepressant-like effects of 17β-estradiol (E2) and prolame in young and middle-aged rats across different post-ovariectomy (Ovx) time frames. Independent groups of young adults and middle-aged female rats were tested in the forced swimming test (FST) at 3, 8, 16, and 24 weeks post-Ovx. Prolame and E2 were administered in a sub-chronic schedule consisting of three injections before the FST. Likewise, the utero-trophic effects of these hormones were analyzed. We found that E2 and prolame reduced immobility in young rats 3 and 8 weeks after Ovx; in contrast, only prolame produced this effect in middle-aged rats three weeks post-Ovx. E2 and prolame increased the animals' utero-somatic index at all post-Ovx times, but the action of E2 and prolame produced a greater response in young adult rats. Our findings showed that the antidepressant-like effects of E2 and prolame depend on the post-Ovx time frame, age, and estrogen type. Interestingly, our results indicate that, in contrast to E2, prolame maintained its antidepressant effect in middle-aged rats.es_ES
dc.formatPDFes_ES
dc.language.isoenges_ES
dc.publisherAcademic Presses_ES
dc.relation141:105154
dc.rightsAcceso Cerradoes_ES
dc.titleEffects of post-ovariectomy time frame and age on the antidepressant-like actions of estradiol and prolame in female ratses_ES
dc.typeArtículoes_ES
dc.contributor.affiliationConsejo Nacional de Ciencia y Tecnología Research Fellow, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Calzada México-Xochimilco 101, Col. San Lorenzo Huipulco, Delegación Tlalpan, 14370 Ciudad de México, Mexico
dc.contributor.emailclemini@unam.mx (C. Lemini); lucia@imp.edu.mx (L. Martínez-Mota)
dc.relation.jnabreviadoHORM BEHAV
dc.relation.journalHormones and Behavior
dc.identifier.placeEstados Unidos
dc.date.published2022
dc.identifier.organizacionInstituto Nacional de Psiquiatría Ramón de la Fuente Muñiz
dc.identifier.eissn1095-6867
dc.identifier.doi10.1016/j.yhbeh.2022.105154
dc.subject.kwEstradiol
dc.subject.kwProlame
dc.subject.kwAntidepressant-like actions
dc.subject.kwPost-ovariectomy time frame
dc.subject.kwAge


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